======= MAEA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAEA
  * **<color #00a2e8>Official Name</color>**: macrophage erythroblast attacher
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10296|10296]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L5Y9|Q7L5Y9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAEA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAEA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. {ECO:0000269|PubMed:16510120, ECO:0000269|PubMed:9763581}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enucleate erythrocyte development|
|GID complex|
|actomyosin contractile ring|
|enucleate erythrocyte differentiation|
|erythrocyte maturation|
|negative regulation of myeloid cell apoptotic process|
|negative regulation of gluconeogenesis|
|regulation of myeloid cell apoptotic process|
|erythrocyte development|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of gluconeogenesis|
|negative regulation of carbohydrate metabolic process|
|myeloid cell development|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|ubiquitin ligase complex|
|myeloid cell homeostasis|
|nuclear matrix|
|regulation of glucose metabolic process|
|spindle|
|anatomical structure maturation|
|regulation of cellular carbohydrate metabolic process|
|cell maturation|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|myeloid cell differentiation|
|developmental maturation|
|ubiquitin-protein transferase activity|
|actin binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|cytoskeleton|
|regulation of small molecule metabolic process|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|hemopoiesis|
|proteolysis involved in cellular protein catabolic process|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|immune system development|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|cell adhesion|
|biological adhesion|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cytoskeleton organization|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|integral component of plasma membrane|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|homeostatic process|
|cell development|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.32|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-3.02|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.62|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.55|
|[[:results:exp539|42°C R08 exp539]]|-2.43|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.37|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.34|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.31|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.13|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.13|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.11|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.08|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.02|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.01|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.9|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.79|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.77|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.76|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.71|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.7|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.71|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.88|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.97|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.17|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.26|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.48|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.54|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.66|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.02|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.07|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.17|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|3.58|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.59|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gid8|GID8]]|0.809|
|[[:human genes:u:ube2h|UBE2H]]|0.805|
|[[:human genes:w:wdr26|WDR26]]|0.697|
|[[:human genes:y:ypel5|YPEL5]]|0.683|
|[[:human genes:r:rmnd5a|RMND5A]]|0.662|
|[[:human genes:r:ranbp9|RANBP9]]|0.468|
|[[:human genes:c:cnot8|CNOT8]]|0.436|
|[[:human genes:m:memo1|MEMO1]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5594
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAEA Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>