======= MALRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MALRD1
  * **<color #00a2e8>Official Name</color>**: MAM and LDL receptor class A domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340895|340895]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VYJ5|Q5VYJ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MALRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MALRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617715|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. {ECO:0000269|PubMed:23747249}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept a|
|MAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of bile acid biosynthetic process|
|negative regulation of bile acid metabolic process|
|regulation of bile acid biosynthetic process|
|regulation of bile acid metabolic process|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|negative regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|negative regulation of lipid metabolic process|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|regulation of steroid metabolic process|
|lipid homeostasis|
|cytoplasmic vesicle membrane|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|Golgi apparatus|
|chemical homeostasis|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.76|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MALRD1 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>