======= MAN2A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAN2A1
  * **<color #00a2e8>Official Name</color>**: mannosidase alpha class 2A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4124|4124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16706|Q16706]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAN2A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAN2A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alpha-mann mid|
|Glyco hydro 38|
|Glyco hydro 38C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydrolase activity, hydrolyzing N-glycosyl compounds|
|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|
|alpha-mannosidase activity|
|mannose metabolic process|
|Golgi medial cisterna|
|N-glycan processing|
|protein deglycosylation|
|lung alveolus development|
|respiratory gaseous exchange by respiratory system|
|retina morphogenesis in camera-type eye|
|cis-Golgi network|
|camera-type eye morphogenesis|
|liver development|
|hepaticobiliary system development|
|vacuole organization|
|retina development in camera-type eye|
|eye morphogenesis|
|hexose metabolic process|
|lung development|
|respiratory tube development|
|carbohydrate binding|
|respiratory system development|
|monosaccharide metabolic process|
|sensory organ morphogenesis|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|camera-type eye development|
|glycoprotein biosynthetic process|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|glycoprotein metabolic process|
|gland development|
|mitochondrion organization|
|positive regulation of neurogenesis|
|carbohydrate metabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neurogenesis|
|tube development|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|carbohydrate derivative metabolic process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.23|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.13|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.82|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAN2A1 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>