======= MAP10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP10
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54627|54627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2G4|Q9P2G4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. {ECO:0000269|PubMed:23264731}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic spindle midzone assembly|
|mitotic spindle elongation|
|spindle elongation|
|spindle midzone assembly|
|mitotic spindle midzone|
|mitotic spindle pole|
|mitotic spindle assembly|
|positive regulation of cytokinesis|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|mitotic spindle organization|
|positive regulation of cell division|
|regulation of cytokinesis|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|midbody|
|regulation of cell division|
|nuclear chromosome segregation|
|regulation of microtubule-based process|
|microtubule binding|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|positive regulation of cell cycle|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.83|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7937
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP10 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>