======= MAP2K3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP2K3
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5606|5606]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46734|P46734]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP2K3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP2K3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602315|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|p38MAPK cascade|
|MAP kinase kinase activity|
|cellular response to vascular endothelial growth factor stimulus|
|positive regulation of blood vessel endothelial cell migration|
|cardiac muscle contraction|
|heart contraction|
|protein tyrosine kinase activity|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|heart process|
|stress-activated MAPK cascade|
|regulation of cytokine biosynthetic process|
|striated muscle contraction|
|positive regulation of epithelial cell migration|
|stress-activated protein kinase signaling cascade|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|regulation of epithelial cell migration|
|muscle contraction|
|positive regulation of MAP kinase activity|
|muscle system process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|protein serine/threonine kinase activity|
|MAPK cascade|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|protein kinase binding|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of cytokine production|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2671
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP2K3 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>