======= MAP2K5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP2K5
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5607|5607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13163|Q13163]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP2K5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP2K5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|PB1|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chemokine (C-X-C motif) ligand 2 production|
|ERK5 cascade|
|negative regulation of interleukin-8 biosynthetic process|
|cellular response to laminar fluid shear stress|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|response to laminar fluid shear stress|
|negative regulation of cell migration involved in sprouting angiogenesis|
|regulation of interleukin-8 biosynthetic process|
|MAP kinase kinase activity|
|negative regulation of interleukin-8 production|
|cellular response to fluid shear stress|
|negative regulation of chemokine production|
|negative regulation of sprouting angiogenesis|
|regulation of heterotypic cell-cell adhesion|
|negative regulation of cytokine biosynthetic process|
|negative regulation of blood vessel endothelial cell migration|
|response to fluid shear stress|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of gastrulation|
|regulation of cell migration involved in sprouting angiogenesis|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of endothelial cell migration|
|negative regulation of response to cytokine stimulus|
|negative regulation of epithelial cell migration|
|regulation of interleukin-8 production|
|regulation of sprouting angiogenesis|
|regulation of chemokine production|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein tyrosine kinase activity|
|regulation of blood vessel endothelial cell migration|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|regulation of cytokine biosynthetic process|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|spindle|
|regulation of embryonic development|
|stress-activated protein kinase signaling cascade|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of cell growth|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|positive regulation of epithelial cell proliferation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of epithelial cell migration|
|negative regulation of apoptotic signaling pathway|
|protein kinase activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|negative regulation of proteolysis|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|cellular response to growth factor stimulus|
|regulation of protein serine/threonine kinase activity|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of growth|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.1|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.66|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16852
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP2K5 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>