======= MAPK14 =======
== Gene Information ==
* **Official Symbol**: MAPK14
* **Official Name**: mitogen-activated protein kinase 14
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1432|1432]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q16539|Q16539]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=MAPK14&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK14|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/600289|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: N/A
|Pkinase|
|Pkinase Tyr|
|positive regulation of interleukin-12 secretion|
|regulation of synaptic membrane adhesion|
|NFAT protein binding|
|mitogen-activated protein kinase p38 binding|
|p38MAPK cascade|
|positive regulation of metallopeptidase activity|
|positive regulation of cytokine secretion involved in immune response|
|regulation of interleukin-12 secretion|
|stress-induced premature senescence|
|positive regulation of brown fat cell differentiation|
|cellular response to lipoteichoic acid|
|response to lipoteichoic acid|
|regulation of metallopeptidase activity|
|MAP kinase activity|
|positive regulation of macrophage chemotaxis|
|regulation of cytokine secretion involved in immune response|
|regulation of brown fat cell differentiation|
|MAP kinase kinase activity|
|response to muscle stretch|
|3-UTR-mediated mRNA stabilization|
|positive regulation of myoblast fusion|
|response to muramyl dipeptide|
|cartilage condensation|
|positive regulation of macrophage migration|
|regulation of myoblast fusion|
|cell aggregation|
|positive regulation of myoblast differentiation|
|positive regulation of cyclase activity|
|positive regulation of cardiac muscle cell proliferation|
|regulation of macrophage chemotaxis|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of erythrocyte differentiation|
|cellular senescence|
|cellular response to virus|
|positive regulation of myotube differentiation|
|positive regulation of cardiac muscle tissue growth|
|lipopolysaccharide-mediated signaling pathway|
|positive regulation of interleukin-12 production|
|positive regulation of protein import into nucleus|
|regulation of macrophage migration|
|positive regulation of heart growth|
|positive regulation of glucose import|
|positive regulation of protein import|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of cytokine production involved in inflammatory response|
|regulation of cardiac muscle cell proliferation|
|regulation of cyclase activity|
|regulation of granulocyte chemotaxis|
|mRNA stabilization|
|positive regulation of glucose transmembrane transport|
|osteoclast differentiation|
|positive regulation of cardiac muscle tissue development|
|regulation of mononuclear cell migration|
|regulation of erythrocyte differentiation|
|positive regulation of organ growth|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|regulation of myoblast differentiation|
|regulation of interleukin-12 production|
|positive regulation of cytokine production involved in immune response|
|regulation of glucose import|
|regulation of protein import into nucleus|
|positive regulation of blood vessel endothelial cell migration|
|regulation of myotube differentiation|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|regulation of protein import|
|negative regulation of RNA catabolic process|
|positive regulation of fat cell differentiation|
|positive regulation of nucleocytoplasmic transport|
|regulation of heart growth|
|cell aging|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|cellular response to ionizing radiation|
|positive regulation of muscle tissue development|
|regulation of glucose transmembrane transport|
|positive regulation of protein localization to nucleus|
|fatty acid oxidation|
|lipid oxidation|
|negative regulation of mRNA metabolic process|
|regulation of cardiac muscle tissue development|
|chondrocyte differentiation|
|regulation of cytokine production involved in immune response|
|protein phosphatase binding|
|positive regulation of muscle cell differentiation|
|positive regulation of leukocyte chemotaxis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of myeloid cell differentiation|
|regulation of organ growth|
|positive regulation of reactive oxygen species metabolic process|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of endothelial cell migration|
|regulation of striated muscle cell differentiation|
|signal transduction in response to DNA damage|
|stress-activated MAPK cascade|
|regulation of nucleocytoplasmic transport|
|myeloid leukocyte differentiation|
|regulation of leukocyte chemotaxis|
|glucose metabolic process|
|secretory granule lumen|
|regulation of protein localization to nucleus|
|spindle pole|
|regulation of fat cell differentiation|
|skeletal muscle tissue development|
|ficolin-1-rich granule lumen|
|positive regulation of leukocyte migration|
|DNA damage checkpoint|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of chemotaxis|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|stress-activated protein kinase signaling cascade|
|DNA integrity checkpoint|
|response to ionizing radiation|
|placenta development|
|regulation of muscle cell differentiation|
|positive regulation of intracellular protein transport|
|activation of MAPK activity|
|hexose metabolic process|
|regulation of endothelial cell migration|
|positive regulation of developmental growth|
|cartilage development|
|peptidyl-serine phosphorylation|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to radiation|
|regulation of mRNA stability|
|regulation of reactive oxygen species metabolic process|
|regulation of signal transduction by p53 class mediator|
|regulation of RNA stability|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|regulation of ossification|
|positive regulation of peptidase activity|
|cellular response to molecule of bacterial origin|
|cell cycle checkpoint|
|regulation of leukocyte migration|
|peptidyl-serine modification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|monosaccharide metabolic process|
|striated muscle cell differentiation|
|regulation of mRNA catabolic process|
|lipid modification|
|positive regulation of transmembrane transport|
|regulation of cytokine secretion|
|positive regulation of intracellular transport|
|negative regulation of Wnt signaling pathway|
|regulation of chemotaxis|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|regulation of synapse organization|
|positive regulation of immune effector process|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|regulation of synapse structure or activity|
|regulation of intracellular protein transport|
|skeletal system morphogenesis|
|cellular response to tumor necrosis factor|
|muscle cell differentiation|
|Ras protein signal transduction|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|aging|
|response to virus|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|positive regulation of peptide secretion|
|muscle organ development|
|muscle tissue development|
|negative regulation of catabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to lipopolysaccharide|
|angiogenesis|
|small GTPase mediated signal transduction|
|fatty acid metabolic process|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|leukocyte differentiation|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|glutamatergic synapse|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|reproductive structure development|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|positive regulation of secretion|
|response to radiation|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|carbohydrate metabolic process|
|muscle structure development|
|blood vessel development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|skeletal system development|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|monocarboxylic acid metabolic process|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|hemopoiesis|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.97|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.37|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.36|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.24|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.23|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.21|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.19|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.12|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.1|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.07|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.04|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.98|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.94|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.91|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.81|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.78|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.7|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.72|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.96|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.08|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.66|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.57|
^Gene^Correlation^
|[[:human genes:c:ccdc101|CCDC101]]|0.562|
|[[:human genes:t:thoc6|THOC6]]|0.551|
|[[:human genes:r:rptor|RPTOR]]|0.543|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.543|
|[[:human genes:r:rnmt|RNMT]]|0.538|
|[[:human genes:a:aars|AARS]]|0.537|
|[[:human genes:a:alg5|ALG5]]|0.536|
|[[:human genes:s:srp68|SRP68]]|0.519|
|[[:human genes:g:gnb1l|GNB1L]]|0.515|
|[[:human genes:g:gmppb|GMPPB]]|0.51|
|[[:human genes:p:pmm2|PMM2]]|0.509|
|[[:human genes:w:wdr24|WDR24]]|0.503|
|[[:human genes:t:tti2|TTI2]]|0.498|
|[[:human genes:o:otud5|OTUD5]]|0.497|
|[[:human genes:m:med16|MED16]]|0.495|
|[[:human genes:m:mllt1|MLLT1]]|0.489|
|[[:human genes:t:tti1|TTI1]]|0.486|
|[[:human genes:e:eny2|ENY2]]|0.481|
|[[:human genes:c:cbfb|CBFB]]|0.478|
|[[:human genes:t:telo2|TELO2]]|0.477|
|[[:human genes:a:arih1|ARIH1]]|0.469|
|[[:human genes:c:csnk2b|CSNK2B]]|0.469|
|[[:human genes:d:dpagt1|DPAGT1]]|0.468|
|[[:human genes:r:rtcb|RTCB]]|0.467|
|[[:human genes:m:mtor|MTOR]]|0.467|
|[[:human genes:a:atf7ip|ATF7IP]]|0.463|
|[[:human genes:m:med23|MED23]]|0.462|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.462|
|[[:human genes:c:cbx3|CBX3]]|0.455|
|[[:human genes:t:thg1l|THG1L]]|0.455|
|[[:human genes:n:nars|NARS]]|0.451|
|[[:human genes:d:dnajc3|DNAJC3]]|0.451|
|[[:human genes:t:tle4|TLE4]]|0.451|
|[[:human genes:e:elac2|ELAC2]]|0.451|
|[[:human genes:t:trmt5|TRMT5]]|0.449|
|[[:human genes:a:alg1|ALG1]]|0.448|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.447|
|[[:human genes:c:cct7|CCT7]]|0.447|
|[[:human genes:t:taf5l|TAF5L]]|0.446|
|[[:human genes:a:atp5j|ATP5J]]|0.446|
|[[:human genes:n:nxt1|NXT1]]|0.445|
|[[:human genes:h:hars|HARS]]|0.445|
|[[:human genes:l:lsmd1|LSMD1]]|0.44|
|[[:human genes:m:map3k4|MAP3K4]]|0.439|
|[[:human genes:e:eif4e|EIF4E]]|0.438|
|[[:human genes:x:xpot|XPOT]]|0.437|
|[[:human genes:t:tmem41b|TMEM41B]]|0.435|
|[[:human genes:r:rpe|RPE]]|0.432|
|[[:human genes:d:dohh|DOHH]]|0.432|
|[[:human genes:t:triap1|TRIAP1]]|0.432|
|[[:human genes:n:nupl2|NUPL2]]|0.432|
|[[:human genes:u:uhrf1|UHRF1]]|0.43|
|[[:human genes:a:adsl|ADSL]]|0.429|
|[[:human genes:p:pax5|PAX5]]|0.427|
|[[:human genes:d:dpf2|DPF2]]|0.426|
|[[:human genes:u:ube2g1|UBE2G1]]|0.425|
|[[:human genes:s:ssbp2|SSBP2]]|0.425|
|[[:human genes:u:ube2l3|UBE2L3]]|0.425|
|[[:human genes:m:med4|MED4]]|0.423|
|[[:human genes:t:tbp|TBP]]|0.422|
|[[:human genes:m:max|MAX]]|0.422|
|[[:human genes:s:srp72|SRP72]]|0.42|
|[[:human genes:a:alg13|ALG13]]|0.417|
|[[:human genes:d:derl2|DERL2]]|0.417|
|[[:human genes:a:alg6|ALG6]]|0.416|
|[[:human genes:v:vrk1|VRK1]]|0.415|
|[[:human genes:l:lsm11|LSM11]]|0.414|
|[[:human genes:u:uba3|UBA3]]|0.413|
|[[:human genes:b:b3gnt2|B3GNT2]]|0.413|
|[[:human genes:m:meaf6|MEAF6]]|0.412|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:y:yars|YARS]]|0.409|
|[[:human genes:p:polr3h|POLR3H]]|0.406|
|[[:human genes:p:pelo|PELO]]|0.405|
|[[:human genes:g:gfpt1|GFPT1]]|0.404|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.404|
|[[:human genes:o:osgep|OSGEP]]|0.403|
|[[:human genes:z:zc3h11a|ZC3H11A]]|0.402|
|[[:human genes:t:tceb3|TCEB3]]|0.402|
|[[:human genes:n:naa20|NAA20]]|0.402|
|[[:human genes:a:alg2|ALG2]]|0.402|
|[[:human genes:t:tada1|TADA1]]|0.401|
|[[:human genes:u:ube3a|UBE3A]]|0.401|
|[[:human genes:s:supt7l|SUPT7L]]|0.4|
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 5214
* **Expression level (log2 read counts)**: 6.99
{{:chemogenomics:nalm6 dist.png?nolink |}}