======= MAPK8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK8
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5599|5599]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45983|P45983]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601158|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase regulator activity|
|regulation of DNA replication origin binding|
|JUN kinase activity|
|JUN phosphorylation|
|basal dendrite|
|positive regulation of deacetylase activity|
|regulation of deacetylase activity|
|MAP kinase activity|
|positive regulation of cyclase activity|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of histone deacetylation|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|cellular response to cadmium ion|
|regulation of protein deacetylation|
|regulation of cyclase activity|
|cellular response to amino acid starvation|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|response to amino acid starvation|
|positive regulation of establishment of protein localization to mitochondrion|
|response to cadmium ion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|cellular response to mechanical stimulus|
|kinase activity|
|regulation of membrane permeability|
|JNK cascade|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|negative regulation of protein binding|
|stress-activated MAPK cascade|
|histone deacetylase binding|
|regulation of circadian rhythm|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|regulation of DNA binding|
|mitochondrial membrane organization|
|cellular response to reactive oxygen species|
|stress-activated protein kinase signaling cascade|
|response to UV|
|regulation of histone modification|
|cellular response to starvation|
|negative regulation of binding|
|regulation of macroautophagy|
|Fc-epsilon receptor signaling pathway|
|positive regulation of apoptotic signaling pathway|
|peptidyl-serine phosphorylation|
|regulation of mitochondrion organization|
|cellular response to lipopolysaccharide|
|regulation of chromatin organization|
|regulation of protein localization to membrane|
|cellular response to metal ion|
|cellular response to molecule of bacterial origin|
|response to starvation|
|response to reactive oxygen species|
|peptidyl-serine modification|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|mitochondrial transport|
|regulation of protein binding|
|cellular response to inorganic substance|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|cellular response to extracellular stimulus|
|rhythmic process|
|axon|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to lipopolysaccharide|
|neuron projection|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|regulation of autophagy|
|cellular response to external stimulus|
|enzyme binding|
|regulation of chromosome organization|
|protein serine/threonine kinase activity|
|response to metal ion|
|MAPK cascade|
|regulation of binding|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|immune response-regulating cell surface receptor signaling pathway|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of cellular protein localization|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|response to bacterium|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|neuron development|
|regulation of cellular catabolic process|
|response to lipid|
|membrane organization|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to cytokine|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.82|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.01|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17428
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK8 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>