======= MAPK9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK9
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5601|5601]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45984|P45984]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602896|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transcription factor catabolic process|
|regulation of transcription factor catabolic process|
|protein localization to tricellular tight junction|
|JUN kinase activity|
|protein localization to cell-cell junction|
|JUN phosphorylation|
|protein localization to cell junction|
|positive regulation of podosome assembly|
|MAP kinase activity|
|positive regulation of macrophage derived foam cell differentiation|
|regulation of podosome assembly|
|regulation of macrophage derived foam cell differentiation|
|protein serine/threonine/tyrosine kinase activity|
|cellular response to cadmium ion|
|response to cadmium ion|
|positive regulation of organelle assembly|
|JNK cascade|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|stress-activated MAPK cascade|
|regulation of circadian rhythm|
|positive regulation of protein ubiquitination|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|cellular response to reactive oxygen species|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|stress-activated protein kinase signaling cascade|
|regulation of ubiquitin-dependent protein catabolic process|
|Fc-epsilon receptor signaling pathway|
|peptidyl-serine phosphorylation|
|positive regulation of apoptotic signaling pathway|
|regulation of proteasomal protein catabolic process|
|cellular response to metal ion|
|response to reactive oxygen species|
|peptidyl-serine modification|
|regulation of protein ubiquitination|
|response to mechanical stimulus|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of organelle assembly|
|cellular response to inorganic substance|
|regulation of protein modification by small protein conjugation or removal|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|regulation of cellular protein catabolic process|
|positive regulation of protein complex assembly|
|rhythmic process|
|neuron projection|
|transcription factor binding|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to metal ion|
|MAPK cascade|
|regulation of protein catabolic process|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of cellular component biogenesis|
|response to inorganic substance|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|neuron development|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of catabolic process|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16935
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK9 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>