======= MAPRE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPRE1
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein RP/EB family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22919|22919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15691|Q15691]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPRE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPRE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603108|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|EB1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule plus-end binding|
|regulation of microtubule plus-end binding|
|cortical microtubule cytoskeleton|
|protein localization to microtubule plus-end|
|mitotic spindle astral microtubule end|
|protein localization to microtubule end|
|positive regulation of microtubule binding|
|cell projection membrane|
|regulation of microtubule binding|
|protein localization to microtubule|
|negative regulation of microtubule polymerization|
|microtubule plus-end binding|
|microtubule plus-end|
|spindle midzone|
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|protein localization to microtubule cytoskeleton|
|negative regulation of microtubule polymerization or depolymerization|
|protein localization to cytoskeleton|
|regulation of microtubule polymerization|
|cytoplasmic microtubule|
|negative regulation of protein polymerization|
|regulation of microtubule polymerization or depolymerization|
|positive regulation of protein binding|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|spindle|
|positive regulation of protein polymerization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|negative regulation of cytoskeleton organization|
|spindle organization|
|microtubule organizing center|
|organelle localization by membrane tethering|
|positive regulation of binding|
|membrane docking|
|regulation of microtubule cytoskeleton organization|
|protein C-terminus binding|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of supramolecular fiber organization|
|regulation of cell cycle G2/M phase transition|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|microtubule binding|
|positive regulation of protein complex assembly|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cadherin binding|
|microtubule|
|cilium assembly|
|regulation of supramolecular fiber organization|
|cilium organization|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|cell cycle process|
|identical protein binding|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|RNA binding|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.87|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.83|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-3.76|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.61|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.23|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.75|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.72|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.51|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.46|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.43|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.35|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.27|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.01|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.97|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.8|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.78|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.54|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kif15|KIF15]]|0.536|
|[[:human genes:t:tacc3|TACC3]]|0.476|
|[[:human genes:d:dlgap5|DLGAP5]]|0.461|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPRE1 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>