======= MARCH5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARCHF5
  * **<color #00a2e8>Official Name</color>**: membrane associated ring-CH-type finger 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54708|54708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX47|Q9NX47]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARCH5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARCH5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610637|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RINGv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitochondrial fission|
|regulation of mitochondrial fission|
|negative regulation of cell aging|
|GTPase binding|
|regulation of cell aging|
|protein autoubiquitination|
|protein localization to mitochondrion|
|positive regulation of mitochondrion organization|
|mitochondrial outer membrane|
|regulation of mitochondrion organization|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|positive regulation of organelle organization|
|protein ubiquitination|
|protein localization to organelle|
|protein modification by small protein conjugation|
|zinc ion binding|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|endoplasmic reticulum|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of developmental process|
|cellular protein localization|
|cellular macromolecule localization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.71|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.72|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.72|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.73|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.76|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.82|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.86|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.87|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.9|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.95|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.97|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.05|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.16|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.16|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.19|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.28|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.29|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.29|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.3|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.31|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.32|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.33|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.36|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.36|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.43|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.51|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.53|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.57|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.57|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.59|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.6|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.62|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.65|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.68|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.73|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.74|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.77|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.85|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.1|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|3.29|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.29|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.33|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.39|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|3.39|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|3.42|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.44|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.46|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.63|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.67|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.88|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.89|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.96|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|4.02|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|4.07|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|4.09|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|4.34|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|4.36|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|4.57|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|4.97|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|5.05|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|5.12|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|5.41|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|5.56|
|[[:results:exp135|MS023 7μM R03 exp135]]|6.52|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|6.96|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|6.98|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|7.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|7.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.846|
|[[:human genes:v:vdac2|VDAC2]]|0.802|
|[[:human genes:u:ubqln1|UBQLN1]]|0.755|
|[[:human genes:c:casp9|CASP9]]|0.751|
|[[:human genes:a:apaf1|APAF1]]|0.744|
|[[:human genes:c:cycs|CYCS]]|0.707|
|[[:human genes:p:plaa|PLAA]]|0.688|
|[[:human genes:h:hccs|HCCS]]|0.67|
|[[:human genes:s:serf2|SERF2]]|0.663|
|[[:human genes:d:diablo|DIABLO]]|0.646|
|[[:human genes:f:faf2|FAF2]]|0.592|
|[[:human genes:s:stau1|STAU1]]|0.585|
|[[:human genes:a:atad1|ATAD1]]|0.559|
|[[:human genes:m:mfn1|MFN1]]|0.558|
|[[:human genes:d:dohh|DOHH]]|0.557|
|[[:human genes:h:hspd1|HSPD1]]|0.522|
|[[:human genes:e:eny2|ENY2]]|0.513|
|[[:human genes:f:fech|FECH]]|0.496|
|[[:human genes:h:hars|HARS]]|0.492|
|[[:human genes:g:gabpa|GABPA]]|0.485|
|[[:human genes:r:romo1|ROMO1]]|0.473|
|[[:human genes:m:metap2|METAP2]]|0.467|
|[[:human genes:m:mlst8|MLST8]]|0.465|
|[[:human genes:r:rptor|RPTOR]]|0.464|
|[[:human genes:p:pmaip1|PMAIP1]]|0.458|
|[[:human genes:t:triap1|TRIAP1]]|0.457|
|[[:human genes:m:mtor|MTOR]]|0.457|
|[[:human genes:u:uap1|UAP1]]|0.45|
|[[:human genes:t:thg1l|THG1L]]|0.448|
|[[:human genes:b:bap1|BAP1]]|0.448|
|[[:human genes:d:ddhd2|DDHD2]]|0.446|
|[[:human genes:g:gfpt1|GFPT1]]|0.443|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.441|
|[[:human genes:z:zzz3|ZZZ3]]|0.438|
|[[:human genes:k:kctd5|KCTD5]]|0.436|
|[[:human genes:s:srrd|SRRD]]|0.43|
|[[:human genes:w:wdr24|WDR24]]|0.428|
|[[:human genes:a:alas1|ALAS1]]|0.428|
|[[:human genes:n:nsd1|NSD1]]|0.427|
|[[:human genes:m:mcl1|MCL1]]|0.424|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.424|
|[[:human genes:r:rad23b|RAD23B]]|0.421|
|[[:human genes:p:pdpk1|PDPK1]]|0.421|
|[[:human genes:k:kdsr|KDSR]]|0.421|
|[[:human genes:m:meaf6|MEAF6]]|0.421|
|[[:human genes:v:vhl|VHL]]|0.42|
|[[:human genes:n:nxt1|NXT1]]|0.417|
|[[:human genes:c:csnk2b|CSNK2B]]|0.413|
|[[:human genes:g:gmppb|GMPPB]]|0.412|
|[[:human genes:n:nae1|NAE1]]|0.41|
|[[:human genes:u:uba3|UBA3]]|0.407|
|[[:human genes:w:wdr59|WDR59]]|0.407|
|[[:human genes:f:fbxo11|FBXO11]]|0.407|
|[[:human genes:m:mios|MIOS]]|0.406|
|[[:human genes:o:opa1|OPA1]]|0.403|
|[[:human genes:a:atp5j|ATP5J]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 63/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|12/28|
|bone|3/26|
|breast|6/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|4/20|
|lung|3/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARCH5 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>