======= MARK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARK1
  * **<color #00a2e8>Official Name</color>**: microtubule affinity regulating kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4139|4139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0L2|Q9P0L2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|KA1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidic acid binding|
|tau-protein kinase activity|
|establishment of mitochondrion localization|
|tau protein binding|
|mitochondrion localization|
|phosphatidylserine binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|neuron migration|
|regulation of dendrite development|
|microtubule cytoskeleton|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|magnesium ion binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|establishment of organelle localization|
|protein serine/threonine kinase activity|
|cytoskeleton|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|microtubule cytoskeleton organization|
|regulation of neuron projection development|
|organelle localization|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|protein phosphorylation|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|cell-cell signaling|
|phosphorylation|
|locomotion|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|intracellular signal transduction|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.13|
|[[:results:exp453|B02 10μM R08 exp453]]|-2|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.88|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.75|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.71|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.76|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARK1 Expression in NALM6 Cells: 3.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>