======= MARK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARK3
  * **<color #00a2e8>Official Name</color>**: microtubule affinity regulating kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4140|4140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27448|P27448]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:28087714}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KA1|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hippo signaling|
|peptidyl-serine autophosphorylation|
|regulation of hippo signaling|
|tau-protein kinase activity|
|tau protein binding|
|positive regulation of protein binding|
|peptidyl-serine phosphorylation|
|positive regulation of binding|
|protein autophosphorylation|
|peptidyl-serine modification|
|regulation of protein binding|
|protein serine/threonine kinase activity|
|MAPK cascade|
|regulation of binding|
|signal transduction by protein phosphorylation|
|dendrite|
|microtubule cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|microtubule-based process|
|peptidyl-amino acid modification|
|protein phosphorylation|
|cytoskeleton organization|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|ATP binding|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.71|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18438
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARK3 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>