======= MARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARS2
  * **<color #00a2e8>Official Name</color>**: methionyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92935|92935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GW9|Q96GW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609728|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1|
|tRNA-synt 1g|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methionyl-tRNA aminoacylation|
|methionine-tRNA ligase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.9|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.75|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.82|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.87|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.95|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.96|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.98|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.99|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.12|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.28|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.688|
|[[:human genes:y:yars2|YARS2]]|0.667|
|[[:human genes:m:mrps16|MRPS16]]|0.663|
|[[:human genes:d:dap3|DAP3]]|0.657|
|[[:human genes:v:vars2|VARS2]]|0.65|
|[[:human genes:n:nars2|NARS2]]|0.646|
|[[:human genes:m:mrps21|MRPS21]]|0.645|
|[[:human genes:r:rars2|RARS2]]|0.635|
|[[:human genes:t:tars2|TARS2]]|0.635|
|[[:human genes:m:mrps14|MRPS14]]|0.627|
|[[:human genes:m:mrps6|MRPS6]]|0.627|
|[[:human genes:g:gfm1|GFM1]]|0.626|
|[[:human genes:p:pars2|PARS2]]|0.621|
|[[:human genes:m:mrpl47|MRPL47]]|0.621|
|[[:human genes:d:dars2|DARS2]]|0.619|
|[[:human genes:l:lars2|LARS2]]|0.614|
|[[:human genes:m:mrps34|MRPS34]]|0.612|
|[[:human genes:e:ears2|EARS2]]|0.61|
|[[:human genes:r:rpusd4|RPUSD4]]|0.606|
|[[:human genes:q:qrsl1|QRSL1]]|0.605|
|[[:human genes:s:selrc1|SELRC1]]|0.603|
|[[:human genes:c:coa3|COA3]]|0.602|
|[[:human genes:m:mrp63|MRP63]]|0.6|
|[[:human genes:h:hars2|HARS2]]|0.598|
|[[:human genes:m:mrps26|MRPS26]]|0.596|
|[[:human genes:m:mrpl3|MRPL3]]|0.589|
|[[:human genes:m:mrpl23|MRPL23]]|0.589|
|[[:human genes:m:mrpl21|MRPL21]]|0.588|
|[[:human genes:m:mrpl20|MRPL20]]|0.583|
|[[:human genes:m:mrps5|MRPS5]]|0.581|
|[[:human genes:m:mrpl53|MRPL53]]|0.581|
|[[:human genes:a:aars2|AARS2]]|0.581|
|[[:human genes:m:mrps12|MRPS12]]|0.578|
|[[:human genes:s:sco2|SCO2]]|0.572|
|[[:human genes:f:ftsj2|FTSJ2]]|0.571|
|[[:human genes:t:tufm|TUFM]]|0.57|
|[[:human genes:t:tefm|TEFM]]|0.568|
|[[:human genes:m:mrps2|MRPS2]]|0.565|
|[[:human genes:c:cox16|COX16]]|0.563|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.562|
|[[:human genes:g:gatc|GATC]]|0.562|
|[[:human genes:p:pet112|PET112]]|0.561|
|[[:human genes:r:rbfa|RBFA]]|0.559|
|[[:human genes:m:mrps25|MRPS25]]|0.558|
|[[:human genes:m:mrps27|MRPS27]]|0.552|
|[[:human genes:n:ndufb11|NDUFB11]]|0.552|
|[[:human genes:f:fastkd5|FASTKD5]]|0.55|
|[[:human genes:p:pnpt1|PNPT1]]|0.549|
|[[:human genes:w:wbscr16|WBSCR16]]|0.549|
|[[:human genes:m:mrpl15|MRPL15]]|0.546|
|[[:human genes:m:mrpl45|MRPL45]]|0.545|
|[[:human genes:r:rpusd3|RPUSD3]]|0.542|
|[[:human genes:c:cox7b|COX7B]]|0.536|
|[[:human genes:b:bcs1l|BCS1L]]|0.535|
|[[:human genes:n:ndufa3|NDUFA3]]|0.532|
|[[:human genes:t:tomm20|TOMM20]]|0.528|
|[[:human genes:f:fars2|FARS2]]|0.525|
|[[:human genes:m:mrps24|MRPS24]]|0.525|
|[[:human genes:m:mtg2|MTG2]]|0.518|
|[[:human genes:c:c10orf2|C10orf2]]|0.516|
|[[:human genes:m:mrps9|MRPS9]]|0.514|
|[[:human genes:s:sars2|SARS2]]|0.514|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.513|
|[[:human genes:m:mrps18a|MRPS18A]]|0.513|
|[[:human genes:g:gfm2|GFM2]]|0.512|
|[[:human genes:t:trub2|TRUB2]]|0.51|
|[[:human genes:m:mrpl12|MRPL12]]|0.509|
|[[:human genes:c:cars2|CARS2]]|0.508|
|[[:human genes:a:aifm1|AIFM1]]|0.508|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.507|
|[[:human genes:m:mrps10|MRPS10]]|0.504|
|[[:human genes:m:mrps7|MRPS7]]|0.503|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.502|
|[[:human genes:t:tfam|TFAM]]|0.5|
|[[:human genes:a:atp5sl|ATP5SL]]|0.499|
|[[:human genes:m:mterfd1|MTERFD1]]|0.497|
|[[:human genes:c:coa6|COA6]]|0.493|
|[[:human genes:m:mrps35|MRPS35]]|0.493|
|[[:human genes:p:polrmt|POLRMT]]|0.492|
|[[:human genes:m:mrpl35|MRPL35]]|0.491|
|[[:human genes:m:mrps22|MRPS22]]|0.49|
|[[:human genes:m:mrps33|MRPS33]]|0.488|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.487|
|[[:human genes:m:mtpap|MTPAP]]|0.487|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.486|
|[[:human genes:c:cox17|COX17]]|0.485|
|[[:human genes:m:mrpl42|MRPL42]]|0.484|
|[[:human genes:a:atp5c1|ATP5C1]]|0.484|
|[[:human genes:p:polg2|POLG2]]|0.484|
|[[:human genes:m:mrpl33|MRPL33]]|0.484|
|[[:human genes:n:ndufa1|NDUFA1]]|0.483|
|[[:human genes:m:mettl17|METTL17]]|0.482|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.48|
|[[:human genes:m:mrpl39|MRPL39]]|0.479|
|[[:human genes:w:wars2|WARS2]]|0.479|
|[[:human genes:s:slc25a26|SLC25A26]]|0.479|
|[[:human genes:m:mrpl18|MRPL18]]|0.478|
|[[:human genes:p:pet117|PET117]]|0.478|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.475|
|[[:human genes:m:mrpl43|MRPL43]]|0.474|
|[[:human genes:m:malsu1|MALSU1]]|0.47|
|[[:human genes:c:c12orf65|C12orf65]]|0.469|
|[[:human genes:n:ndufa2|NDUFA2]]|0.468|
|[[:human genes:c:cox15|COX15]]|0.464|
|[[:human genes:c:cox11|COX11]]|0.461|
|[[:human genes:t:tfb1m|TFB1M]]|0.46|
|[[:human genes:e:eral1|ERAL1]]|0.46|
|[[:human genes:p:polg|POLG]]|0.458|
|[[:human genes:e:ecsit|ECSIT]]|0.457|
|[[:human genes:m:mrpl51|MRPL51]]|0.457|
|[[:human genes:p:ptcd3|PTCD3]]|0.454|
|[[:human genes:m:mtif2|MTIF2]]|0.452|
|[[:human genes:m:mrpl4|MRPL4]]|0.451|
|[[:human genes:n:nsun4|NSUN4]]|0.451|
|[[:human genes:n:ndufv1|NDUFV1]]|0.449|
|[[:human genes:m:mtg1|MTG1]]|0.446|
|[[:human genes:m:mrps11|MRPS11]]|0.444|
|[[:human genes:m:mrpl55|MRPL55]]|0.443|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.442|
|[[:human genes:m:mterfd2|MTERFD2]]|0.442|
|[[:human genes:m:mrpl28|MRPL28]]|0.441|
|[[:human genes:m:mrpl11|MRPL11]]|0.441|
|[[:human genes:m:mrps23|MRPS23]]|0.44|
|[[:human genes:m:mrpl13|MRPL13]]|0.439|
|[[:human genes:m:mrpl37|MRPL37]]|0.437|
|[[:human genes:t:trmt10c|TRMT10C]]|0.436|
|[[:human genes:p:pgm3|PGM3]]|0.434|
|[[:human genes:m:mrpl52|MRPL52]]|0.433|
|[[:human genes:n:ndufs5|NDUFS5]]|0.432|
|[[:human genes:n:ndufc2|NDUFC2]]|0.432|
|[[:human genes:a:atp5b|ATP5B]]|0.432|
|[[:human genes:n:ndufb6|NDUFB6]]|0.43|
|[[:human genes:m:mrpl17|MRPL17]]|0.429|
|[[:human genes:n:ndufa10|NDUFA10]]|0.428|
|[[:human genes:m:mrpl2|MRPL2]]|0.427|
|[[:human genes:m:mrpl44|MRPL44]]|0.425|
|[[:human genes:m:mrpl22|MRPL22]]|0.424|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.424|
|[[:human genes:t:tfb2m|TFB2M]]|0.423|
|[[:human genes:t:tmem242|TMEM242]]|0.422|
|[[:human genes:a:atp5d|ATP5D]]|0.422|
|[[:human genes:m:mrpl34|MRPL34]]|0.421|
|[[:human genes:m:mipep|MIPEP]]|0.421|
|[[:human genes:h:higd2a|HIGD2A]]|0.42|
|[[:human genes:t:tomm7|TOMM7]]|0.42|
|[[:human genes:n:ndufs2|NDUFS2]]|0.42|
|[[:human genes:m:mrpl36|MRPL36]]|0.419|
|[[:human genes:a:atp5e|ATP5E]]|0.418|
|[[:human genes:m:mrpl49|MRPL49]]|0.417|
|[[:human genes:d:ddx28|DDX28]]|0.417|
|[[:human genes:n:ndufa11|NDUFA11]]|0.416|
|[[:human genes:a:atp5a1|ATP5A1]]|0.416|
|[[:human genes:e:elac2|ELAC2]]|0.416|
|[[:human genes:c:chchd1|CHCHD1]]|0.415|
|[[:human genes:c:coa5|COA5]]|0.415|
|[[:human genes:l:lrpprc|LRPPRC]]|0.414|
|[[:human genes:c:coq2|COQ2]]|0.413|
|[[:human genes:n:ndufb9|NDUFB9]]|0.412|
|[[:human genes:g:grsf1|GRSF1]]|0.411|
|[[:human genes:p:ppa2|PPA2]]|0.411|
|[[:human genes:t:tomm22|TOMM22]]|0.41|
|[[:human genes:f:fastkd2|FASTKD2]]|0.408|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.407|
|[[:human genes:t:tmem261|TMEM261]]|0.406|
|[[:human genes:l:lsm10|LSM10]]|0.405|
|[[:human genes:u:uqcr10|UQCR10]]|0.404|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.404|
|[[:human genes:m:mtif3|MTIF3]]|0.403|
|[[:human genes:p:pdss1|PDSS1]]|0.402|
|[[:human genes:m:mrpl27|MRPL27]]|0.401|
|[[:human genes:c:cox19|COX19]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 524/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|21/28|
|bone|17/26|
|breast|25/33|
|central nervous system|36/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|13/21|
|liver|15/20|
|lung|59/75|
|lymphocyte|10/16|
|ovary|16/26|
|pancreas|14/24|
|peripheral nervous system|10/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|19/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARS2 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>