======= MBOAT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBOAT7
  * **<color #00a2e8>Official Name</color>**: membrane bound O-acyltransferase domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79143|79143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96N66|Q96N66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBOAT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBOAT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBOAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2-acylglycerol-3-phosphate O-acyltransferase activity|
|lysophospholipid acyltransferase activity|
|layer formation in cerebral cortex|
|mitochondria-associated endoplasmic reticulum membrane|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|phosphatidylinositol acyl-chain remodeling|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|ventricular system development|
|cerebral cortex radially oriented cell migration|
|glial cell migration|
|cerebral cortex cell migration|
|telencephalon cell migration|
|forebrain cell migration|
|cerebral cortex development|
|phosphatidylinositol metabolic process|
|pallium development|
|gliogenesis|
|phospholipid biosynthetic process|
|telencephalon development|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|forebrain development|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|brain development|
|head development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|cell migration|
|central nervous system development|
|localization of cell|
|cell motility|
|lipid metabolic process|
|locomotion|
|movement of cell or subcellular component|
|neurogenesis|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.79|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.75|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.34|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBOAT7 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>