======= MC1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MC1R
  * **<color #00a2e8>Official Name</color>**: melanocortin 1 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4157|4157]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01726|Q01726]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MC1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MC1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155555|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melanocyte-stimulating hormone receptor activity|
|melanocortin receptor activity|
|positive regulation of protein kinase A signaling|
|positive regulation of protein kinase C signaling|
|melanin biosynthetic process|
|UV protection|
|melanin metabolic process|
|UV-damage excision repair|
|regulation of protein kinase C signaling|
|secondary metabolite biosynthetic process|
|regulation of protein kinase A signaling|
|phenol-containing compound biosynthetic process|
|G protein-coupled peptide receptor activity|
|pigment biosynthetic process|
|secondary metabolic process|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|pigment metabolic process|
|sensory perception of pain|
|phenol-containing compound metabolic process|
|cellular response to UV|
|pigmentation|
|cellular response to light stimulus|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|response to UV|
|cAMP-mediated signaling|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of protein kinase B signaling|
|cyclic-nucleotide-mediated signaling|
|cellular response to radiation|
|organic hydroxy compound biosynthetic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of protein kinase B signaling|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of cytokine production|
|ubiquitin protein ligase binding|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|second-messenger-mediated signaling|
|response to radiation|
|organic hydroxy compound metabolic process|
|DNA repair|
|regulation of cytokine production|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|sensory perception|
|positive regulation of intracellular signal transduction|
|response to abiotic stimulus|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3818
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MC1R Expression in NALM6 Cells: 2.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>