======= MCF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCF2
  * **<color #00a2e8>Official Name</color>**: MCF.2 cell line derived transforming sequence
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4168|4168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10911|P10911]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/311030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of axonogenesis|
|Rho guanyl-nucleotide exchange factor activity|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|negative regulation of cell morphogenesis involved in differentiation|
|dendrite development|
|regulation of Rho protein signal transduction|
|negative regulation of neuron projection development|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|negative regulation of neuron differentiation|
|regulation of Ras protein signal transduction|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.95|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.74|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.89|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCF2 Expression in NALM6 Cells: 1.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>