======= MCF2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCF2L
  * **<color #00a2e8>Official Name</color>**: MCF.2 cell line derived transforming sequence like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23263|23263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15068|O15068]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCF2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCF2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
|Spectrin|
|SH3 2|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho guanyl-nucleotide exchange factor activity|
|endomembrane system|
|phosphatidylinositol binding|
|regulation of Rho protein signal transduction|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|G protein-coupled receptor signaling pathway|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell death|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.9|
|[[:results:exp453|B02 10μM R08 exp453]]|1.83|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.86|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.466|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.435|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.425|
|[[:human genes:s:snrpa1|SNRPA1]]|0.416|
|[[:human genes:e:exosc3|EXOSC3]]|0.414|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.41|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.409|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.406|
|[[:human genes:k:krt78|KRT78]]|0.402|
|[[:human genes:t:ticrr|TICRR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCF2L Expression in NALM6 Cells: 1.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>