======= MCM9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCM9
  * **<color #00a2e8>Official Name</color>**: minichromosome maintenance 9 homologous recombination repair factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=254394|254394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXL9|Q9NXL9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCM9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCM9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. {ECO:0000269|PubMed:22771115}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 5|
|MCM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication|
|MCM8-MCM9 complex|
|recombinational interstrand cross-link repair|
|MutSbeta complex binding|
|MutLbeta complex binding|
|MutSalpha complex binding|
|MCM complex|
|DNA replication origin binding|
|protein localization to chromatin|
|mismatch repair|
|DNA-dependent DNA replication maintenance of fidelity|
|interstrand cross-link repair|
|DNA helicase activity|
|protein localization to chromosome|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|DNA duplex unwinding|
|DNA geometric change|
|DNA-dependent DNA replication|
|chromosome|
|female gamete generation|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|protein-containing complex binding|
|DNA conformation change|
|enzyme binding|
|chromatin binding|
|DNA repair|
|gamete generation|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-4.83|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-4.81|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-3.84|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.54|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-3.1|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-3.05|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-3.04|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-3.04|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.99|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.69|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.6|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.55|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.53|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.45|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.45|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.43|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.37|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.37|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.32|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.31|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.3|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.28|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.27|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.24|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.2|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.16|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.09|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.08|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.07|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.07|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.05|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.04|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.01|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.99|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.97|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.96|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.96|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.91|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.89|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.88|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.88|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.87|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.86|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.84|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.81|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.81|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.79|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.75|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.75|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.74|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.74|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.72|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.71|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.08|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.34|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcm8|MCM8]]|0.559|
|[[:human genes:m:mad2l2|MAD2L2]]|0.514|
|[[:human genes:x:xrcc2|XRCC2]]|0.495|
|[[:human genes:s:spidr|SPIDR]]|0.484|
|[[:human genes:r:rad51b|RAD51B]]|0.484|
|[[:human genes:r:rad51d|RAD51D]]|0.457|
|[[:human genes:s:swsap1|SWSAP1]]|0.439|
|[[:human genes:t:ten1|TEN1]]|0.439|
|[[:human genes:s:sfr1|SFR1]]|0.425|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.417|
|[[:human genes:s:swi5|SWI5]]|0.416|
|[[:human genes:c:chtf8|CHTF8]]|0.415|
|[[:human genes:z:zswim7|ZSWIM7]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3164
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCM9 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>