======= MCRS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCRS1
  * **<color #00a2e8>Official Name</color>**: microspherule protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10445|10445]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EZ8|Q96EZ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCRS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCRS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). {ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein localization to nucleolus|
|NSL complex|
|G-quadruplex RNA binding|
|regulation of protein localization to nucleolus|
|poly(G) binding|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|histone H4-K5 acetylation|
|Ino80 complex|
|histone H4-K8 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|poly(U) RNA binding|
|MLL1 complex|
|polysome|
|histone H4 acetylation|
|positive regulation of protein localization to nucleus|
|histone acetylation|
|regulation of protein localization to nucleus|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|perikaryon|
|protein acetylation|
|protein acylation|
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|positive regulation of cellular protein localization|
|histone modification|
|covalent chromatin modification|
|dendrite|
|DNA repair|
|regulation of cellular protein localization|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|endoplasmic reticulum|
|regulation of protein localization|
|chromosome organization|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.7|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.532|
|[[:human genes:k:kansl1|KANSL1]]|0.519|
|[[:human genes:p:prim1|PRIM1]]|0.468|
|[[:human genes:e:eif2s1|EIF2S1]]|0.422|
|[[:human genes:k:kansl2|KANSL2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 917
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCRS1 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>