======= MDH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MDH1
  * **<color #00a2e8>Official Name</color>**: malate dehydrogenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4190|4190]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40925|P40925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MDH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MDH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldh 1 C|
|Ldh 1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diiodophenylpyruvate reductase activity|
|L-malate dehydrogenase activity|
|malic enzyme activity|
|malate metabolic process|
|oxaloacetate metabolic process|
|tricarboxylic acid cycle|
|NADH metabolic process|
|NAD binding|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|glucose metabolic process|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|cellular respiration|
|monosaccharide metabolic process|
|energy derivation by oxidation of organic compounds|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|extracellular space|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-4.26|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.72|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.74|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.76|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.79|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.85|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.85|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.87|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.88|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.89|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.94|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.97|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.98|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.02|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.05|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.06|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.12|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.14|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.16|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.17|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.17|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.2|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.24|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.35|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.35|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.38|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.46|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.46|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.67|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.73|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.91|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.97|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.04|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|3.04|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|3.18|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|3.21|
|[[:results:exp224|CB-839 10μM R05 exp224]]|3.64|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|4.01|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|4.54|
|[[:results:exp274|Citral 50μM R06 exp274]]|5.29|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|7.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pdha1|PDHA1]]|0.559|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.547|
|[[:human genes:p:pdhb|PDHB]]|0.533|
|[[:human genes:p:pdp2|PDP2]]|0.458|
|[[:human genes:m:mpc1|MPC1]]|0.443|
|[[:human genes:a:acsl4|ACSL4]]|0.426|
|[[:human genes:a:arrdc3|ARRDC3]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MDH1 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>