======= MDM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MDM2
  * **<color #00a2e8>Official Name</color>**: MDM2 proto-oncogene
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4193|4193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00987|Q00987]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MDM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MDM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SWIB|
|zf-RanBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to formaldehyde|
|cellular response to vitamin B1|
|NEDD8 ligase activity|
|transcription factor catabolic process|
|response to vitamin B1|
|cellular response to actinomycin D|
|traversing start control point of mitotic cell cycle|
|response to actinomycin D|
|response to water-immersion restraint stress|
|receptor serine/threonine kinase binding|
|cellular response to UV-C|
|amyloid fibril formation|
|5S rRNA binding|
|response to ether|
|peroxisome proliferator activated receptor binding|
|ligase activity|
|cellular response to estrogen stimulus|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|response to UV-C|
|SUMO transferase activity|
|positive regulation of vascular associated smooth muscle cell migration|
|response to magnesium ion|
|atrial septum development|
|positive regulation of protein export from nucleus|
|regulation of vascular associated smooth muscle cell migration|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of cell cycle arrest|
|cellular response to vitamin|
|atrioventricular valve morphogenesis|
|atrioventricular valve development|
|response to immobilization stress|
|cellular response to gamma radiation|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of signal transduction by p53 class mediator|
|blood vessel remodeling|
|ribonucleoprotein complex binding|
|response to isoquinoline alkaloid|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|response to morphine|
|positive regulation of vascular smooth muscle cell proliferation|
|response to iron ion|
|disordered domain specific binding|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|cellular response to alkaloid|
|cardiac atrium development|
|endocardial cushion morphogenesis|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of smooth muscle cell migration|
|regulation of protein export from nucleus|
|endocardial cushion development|
|protein destabilization|
|positive regulation of cell cycle G1/S phase transition|
|regulation of vascular smooth muscle cell proliferation|
|mesenchyme morphogenesis|
|heart valve morphogenesis|
|response to cocaine|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|response to gamma radiation|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|scaffold protein binding|
|regulation of smooth muscle cell migration|
|heart valve development|
|positive regulation of nucleocytoplasmic transport|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|protein autoubiquitination|
|p53 binding|
|protein sumoylation|
|regulation of protein processing|
|cellular response to nutrient|
|regulation of protein maturation|
|endocytic vesicle membrane|
|cellular response to ionizing radiation|
|cellular response to hydrogen peroxide|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|ventricular septum development|
|cardiac septum morphogenesis|
|response to estrogen|
|positive regulation of mitotic cell cycle phase transition|
|response to anesthetic|
|DNA damage response, signal transduction by p53 class mediator|
|negative regulation of response to DNA damage stimulus|
|positive regulation of cell cycle arrest|
|ubiquitin binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|cellular response to UV|
|positive regulation of smooth muscle cell proliferation|
|response to vitamin|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of cell cycle phase transition|
|mitotic DNA damage checkpoint|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of heart rate|
|positive regulation of ubiquitin-dependent protein catabolic process|
|tissue remodeling|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of cell cycle G1/S phase transition|
|regulation of nucleocytoplasmic transport|
|regulation of cell cycle arrest|
|protein N-terminus binding|
|cardiac septum development|
|response to alkaloid|
|cellular response to light stimulus|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|signal transduction by p53 class mediator|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|cellular response to reactive oxygen species|
|DNA damage checkpoint|
|regulation of smooth muscle cell proliferation|
|positive regulation of cellular protein catabolic process|
|response to UV|
|DNA integrity checkpoint|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|regulation of intrinsic apoptotic signaling pathway|
|protein localization to nucleus|
|regulation of cell cycle G1/S phase transition|
|cardiac chamber development|
|cellular response to radiation|
|regulation of signal transduction by p53 class mediator|
|negative regulation of cell projection organization|
|regulation of proteasomal protein catabolic process|
|response to ammonium ion|
|cellular response to hypoxia|
|cell cycle checkpoint|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|positive regulation of intracellular transport|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to nutrient|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of response to DNA damage stimulus|
|mesenchyme development|
|ubiquitin protein ligase activity|
|negative regulation of apoptotic signaling pathway|
|negative regulation of neuron differentiation|
|negative regulation of cell cycle phase transition|
|regulation of intracellular protein transport|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|regulation of heart contraction|
|negative regulation of endopeptidase activity|
|protein domain specific binding|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|heart morphogenesis|
|negative regulation of peptidase activity|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|synapse|
|protein deubiquitination|
|nuclear body|
|positive regulation of cell cycle process|
|regulation of protein stability|
|regulation of blood circulation|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|response to xenobiotic stimulus|
|response to antibiotic|
|negative regulation of mitotic cell cycle|
|response to light stimulus|
|negative regulation of nervous system development|
|peptidyl-lysine modification|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|cellular response to peptide|
|response to steroid hormone|
|negative regulation of cell development|
|cellular response to external stimulus|
|response to hypoxia|
|enzyme binding|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to metal ion|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of protein catabolic process|
|response to oxidative stress|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|response to radiation|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|response to peptide|
|blood vessel development|
|regulation of neuron projection development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|response to growth factor|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|tissue morphogenesis|
|negative regulation of cell cycle|
|regulation of system process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|zinc ion binding|
|regulation of cell migration|
|response to lipid|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-3.33|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.03|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.66|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.65|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.64|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.62|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.59|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.57|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.53|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.35|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.32|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.29|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.25|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.2|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.2|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.17|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.13|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.07|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.02|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.02|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.94|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.92|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.89|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.89|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.84|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.83|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.77|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.75|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.7|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.71|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.77|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.83|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.83|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.97|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.01|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.22|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.543|
|[[:human genes:c:c14orf93|C14orf93]]|0.529|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.523|
|[[:human genes:r:rpl35|RPL35]]|0.515|
|[[:human genes:p:polr2j3|POLR2J3]]|0.509|
|[[:human genes:s:ssh2|SSH2]]|0.508|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.504|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.488|
|[[:human genes:p:pole|POLE]]|0.488|
|[[:human genes:s:smg7|SMG7]]|0.486|
|[[:human genes:v:vasn|VASN]]|0.483|
|[[:human genes:c:cope|COPE]]|0.481|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.48|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.48|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.479|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.478|
|[[:human genes:s:supt6h|SUPT6H]]|0.476|
|[[:human genes:m:mt1e|MT1E]]|0.47|
|[[:human genes:p:prim1|PRIM1]]|0.469|
|[[:human genes:p:psmd1|PSMD1]]|0.467|
|[[:human genes:r:rad21|RAD21]]|0.464|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:f:fbxw9|FBXW9]]|0.462|
|[[:human genes:c:cdca3|CDCA3]]|0.461|
|[[:human genes:r:rps3a|RPS3A]]|0.457|
|[[:human genes:c:cbwd6|CBWD6]]|0.456|
|[[:human genes:t:tceb3c|TCEB3C]]|0.456|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.456|
|[[:human genes:c:cbwd5|CBWD5]]|0.455|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.452|
|[[:human genes:c:cbwd3|CBWD3]]|0.449|
|[[:human genes:p:psmb4|PSMB4]]|0.448|
|[[:human genes:r:rps2|RPS2]]|0.445|
|[[:human genes:p:psmc1|PSMC1]]|0.445|
|[[:human genes:o:orc1|ORC1]]|0.442|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.442|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.442|
|[[:human genes:g:golga8o|GOLGA8O]]|0.44|
|[[:human genes:c:ccna2|CCNA2]]|0.435|
|[[:human genes:s:s1pr4|S1PR4]]|0.435|
|[[:human genes:r:rad51|RAD51]]|0.432|
|[[:human genes:a:atp13a1|ATP13A1]]|0.431|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.429|
|[[:human genes:p:psmb1|PSMB1]]|0.426|
|[[:human genes:s:scaf1|SCAF1]]|0.426|
|[[:human genes:n:nupl1|NUPL1]]|0.426|
|[[:human genes:s:slc4a1|SLC4A1]]|0.426|
|[[:human genes:c:chd4|CHD4]]|0.425|
|[[:human genes:n:nup155|NUP155]]|0.424|
|[[:human genes:s:supt5h|SUPT5H]]|0.424|
|[[:human genes:n:ndc80|NDC80]]|0.423|
|[[:human genes:n:nup188|NUP188]]|0.423|
|[[:human genes:u:uqcrh|UQCRH]]|0.423|
|[[:human genes:r:rps5|RPS5]]|0.423|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.423|
|[[:human genes:l:lad1|LAD1]]|0.422|
|[[:human genes:r:rps12|RPS12]]|0.419|
|[[:human genes:r:rnf4|RNF4]]|0.419|
|[[:human genes:c:cwc22|CWC22]]|0.418|
|[[:human genes:p:psmb2|PSMB2]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.417|
|[[:human genes:r:rpl38|RPL38]]|0.417|
|[[:human genes:b:bysl|BYSL]]|0.417|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.416|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.416|
|[[:human genes:p:psmd6|PSMD6]]|0.415|
|[[:human genes:k:krt78|KRT78]]|0.413|
|[[:human genes:n:nol12|NOL12]]|0.413|
|[[:human genes:c:cdc73|CDC73]]|0.413|
|[[:human genes:d:ddx56|DDX56]]|0.413|
|[[:human genes:p:psmd11|PSMD11]]|0.413|
|[[:human genes:p:psmd3|PSMD3]]|0.413|
|[[:human genes:t:traip|TRAIP]]|0.412|
|[[:human genes:m:myo1h|MYO1H]]|0.41|
|[[:human genes:n:nup205|NUP205]]|0.41|
|[[:human genes:a:akirin2|AKIRIN2]]|0.409|
|[[:human genes:e:exosc9|EXOSC9]]|0.409|
|[[:human genes:c:ckap5|CKAP5]]|0.408|
|[[:human genes:s:slc38a7|SLC38A7]]|0.408|
|[[:human genes:s:smg1|SMG1]]|0.408|
|[[:human genes:k:kctd17|KCTD17]]|0.408|
|[[:human genes:a:ankle2|ANKLE2]]|0.407|
|[[:human genes:c:chmp2a|CHMP2A]]|0.407|
|[[:human genes:n:npipb8|NPIPB8]]|0.407|
|[[:human genes:c:cgb2|CGB2]]|0.405|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.405|
|[[:human genes:r:rilpl2|RILPL2]]|0.405|
|[[:human genes:r:rps3|RPS3]]|0.405|
|[[:human genes:r:rbbp5|RBBP5]]|0.405|
|[[:human genes:r:ranbp2|RANBP2]]|0.404|
|[[:human genes:t:ticrr|TICRR]]|0.404|
|[[:human genes:n:nop16|NOP16]]|0.403|
|[[:human genes:p:psmd7|PSMD7]]|0.403|
|[[:human genes:w:wdr43|WDR43]]|0.403|
|[[:human genes:r:rnf113a|RNF113A]]|0.402|
|[[:human genes:p:psmc6|PSMC6]]|0.402|
|[[:human genes:r:rps6|RPS6]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 94/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|13/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MDM2 Expression in NALM6 Cells: 8.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>