======= MDN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MDN1
  * **<color #00a2e8>Official Name</color>**: midasin AAA ATPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23195|23195]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NU22|Q9NU22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MDN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MDN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre- 60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). {ECO:0000250|UniProtKB:Q12019, ECO:0000269|PubMed:27814492}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 3|
|AAA 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal large subunit assembly|
|intermediate filament cytoskeleton|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|unfolded protein binding|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ATPase activity|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|ATP binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.27|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.73|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.74|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.74|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.8|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.84|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.91|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.92|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.93|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.04|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.07|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.2|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.601|
|[[:human genes:p:polr2j3|POLR2J3]]|0.591|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:t:ticrr|TICRR]]|0.45|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.446|
|[[:human genes:k:krt78|KRT78]]|0.445|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.437|
|[[:human genes:t:tyms|TYMS]]|0.437|
|[[:human genes:i:ik|IK]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.42|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.405|
|[[:human genes:d:dhx38|DHX38]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 708/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|26/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|19/20|
|lung|68/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 532
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MDN1 Expression in NALM6 Cells: 9.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>