======= MED13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED13
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9969|9969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHV7|Q9UHV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603808|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med13 N|
|Med13 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin D receptor binding|
|thyroid hormone receptor binding|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|mediator complex|
|nuclear receptor transcription coactivator activity|
|cholesterol homeostasis|
|sterol homeostasis|
|transcription coregulator activity|
|lipid homeostasis|
|negative regulation of DNA-binding transcription factor activity|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|regulation of DNA-binding transcription factor activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.27|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.04|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.01|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.9|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.9|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.5|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.98|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.37|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.58|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13l|MED13L]]|0.67|
|[[:human genes:t:taf6l|TAF6L]]|0.621|
|[[:human genes:c:ccnc|CCNC]]|0.591|
|[[:human genes:h:hdac8|HDAC8]]|0.573|
|[[:human genes:t:taf5l|TAF5L]]|0.569|
|[[:human genes:m:med10|MED10]]|0.566|
|[[:human genes:p:prr12|PRR12]]|0.562|
|[[:human genes:m:mllt1|MLLT1]]|0.549|
|[[:human genes:t:tada2b|TADA2B]]|0.543|
|[[:human genes:t:tada1|TADA1]]|0.535|
|[[:human genes:s:supt7l|SUPT7L]]|0.533|
|[[:human genes:i:ing5|ING5]]|0.509|
|[[:human genes:t:tada3|TADA3]]|0.503|
|[[:human genes:m:med23|MED23]]|0.501|
|[[:human genes:e:ehmt2|EHMT2]]|0.501|
|[[:human genes:m:med7|MED7]]|0.487|
|[[:human genes:z:zc3h18|ZC3H18]]|0.482|
|[[:human genes:b:brpf1|BRPF1]]|0.475|
|[[:human genes:c:clk3|CLK3]]|0.474|
|[[:human genes:m:med1|MED1]]|0.469|
|[[:human genes:z:znf592|ZNF592]]|0.463|
|[[:human genes:b:btaf1|BTAF1]]|0.46|
|[[:human genes:c:ccdc101|CCDC101]]|0.457|
|[[:human genes:a:aff1|AFF1]]|0.451|
|[[:human genes:u:ube3a|UBE3A]]|0.442|
|[[:human genes:t:thoc6|THOC6]]|0.44|
|[[:human genes:f:fbxo11|FBXO11]]|0.437|
|[[:human genes:f:fli1|FLI1]]|0.434|
|[[:human genes:d:dcaf7|DCAF7]]|0.433|
|[[:human genes:s:supt20h|SUPT20H]]|0.431|
|[[:human genes:u:ube2g1|UBE2G1]]|0.428|
|[[:human genes:u:uxs1|UXS1]]|0.427|
|[[:human genes:a:atxn7|ATXN7]]|0.425|
|[[:human genes:s:sirt7|SIRT7]]|0.425|
|[[:human genes:c:csrnp1|CSRNP1]]|0.42|
|[[:human genes:k:kat2a|KAT2A]]|0.415|
|[[:human genes:m:max|MAX]]|0.414|
|[[:human genes:m:med16|MED16]]|0.412|
|[[:human genes:t:tceb3|TCEB3]]|0.411|
|[[:human genes:z:znf706|ZNF706]]|0.41|
|[[:human genes:l:lsm12|LSM12]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1211
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED13 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>