======= MED13L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED13L
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 13L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23389|23389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q71F56|Q71F56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED13L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED13L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608771|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med13 N|
|Med13 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mediator complex|
|transcription coregulator activity|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.76|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.71|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.74|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.76|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.8|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.82|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.86|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.02|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.09|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.25|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.36|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.09|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.67|
|[[:human genes:z:znf592|ZNF592]]|0.551|
|[[:human genes:b:brpf1|BRPF1]]|0.55|
|[[:human genes:t:tada2b|TADA2B]]|0.55|
|[[:human genes:s:supt7l|SUPT7L]]|0.539|
|[[:human genes:t:taf5l|TAF5L]]|0.535|
|[[:human genes:m:mllt1|MLLT1]]|0.52|
|[[:human genes:t:taf6l|TAF6L]]|0.516|
|[[:human genes:i:ing5|ING5]]|0.51|
|[[:human genes:c:ccnc|CCNC]]|0.508|
|[[:human genes:f:fbxo11|FBXO11]]|0.506|
|[[:human genes:h:hdac8|HDAC8]]|0.505|
|[[:human genes:a:aff1|AFF1]]|0.5|
|[[:human genes:m:med23|MED23]]|0.5|
|[[:human genes:z:zc3h18|ZC3H18]]|0.496|
|[[:human genes:m:med10|MED10]]|0.489|
|[[:human genes:t:tada3|TADA3]]|0.485|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.475|
|[[:human genes:d:dek|DEK]]|0.473|
|[[:human genes:d:dcaf7|DCAF7]]|0.469|
|[[:human genes:t:thoc6|THOC6]]|0.468|
|[[:human genes:u:ube2g1|UBE2G1]]|0.463|
|[[:human genes:t:tada1|TADA1]]|0.454|
|[[:human genes:c:clk3|CLK3]]|0.454|
|[[:human genes:u:ubr5|UBR5]]|0.448|
|[[:human genes:t:tceb3|TCEB3]]|0.448|
|[[:human genes:m:med7|MED7]]|0.447|
|[[:human genes:p:prr12|PRR12]]|0.446|
|[[:human genes:a:atxn7|ATXN7]]|0.443|
|[[:human genes:d:dcaf5|DCAF5]]|0.443|
|[[:human genes:e:ehmt2|EHMT2]]|0.442|
|[[:human genes:v:vcpip1|VCPIP1]]|0.424|
|[[:human genes:m:max|MAX]]|0.424|
|[[:human genes:k:kat2a|KAT2A]]|0.423|
|[[:human genes:a:actb|ACTB]]|0.422|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.422|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.422|
|[[:human genes:z:zranb1|ZRANB1]]|0.42|
|[[:human genes:m:mllt10|MLLT10]]|0.416|
|[[:human genes:c:csrnp1|CSRNP1]]|0.415|
|[[:human genes:s:sirt7|SIRT7]]|0.414|
|[[:human genes:w:wdr24|WDR24]]|0.414|
|[[:human genes:p:pus10|PUS10]]|0.413|
|[[:human genes:c:ccdc101|CCDC101]]|0.411|
|[[:human genes:h:hhex|HHEX]]|0.409|
|[[:human genes:f:fnip1|FNIP1]]|0.406|
|[[:human genes:m:med25|MED25]]|0.404|
|[[:human genes:f:fli1|FLI1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED13L Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>