======= MEF2D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEF2D
  * **<color #00a2e8>Official Name</color>**: myocyte enhancer factor 2D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4209|4209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14814|Q14814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEF2D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEF2D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HJURP C|
|SRF-TF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adult heart development|
|replacement ossification|
|endochondral ossification|
|activating transcription factor binding|
|positive regulation of vascular smooth muscle cell proliferation|
|skeletal muscle cell differentiation|
|regulation of vascular smooth muscle cell proliferation|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|positive regulation of smooth muscle cell proliferation|
|histone deacetylase binding|
|bone morphogenesis|
|skeletal muscle tissue development|
|osteoblast differentiation|
|skeletal muscle organ development|
|regulation of smooth muscle cell proliferation|
|cartilage development|
|bone development|
|connective tissue development|
|nuclear chromatin|
|skeletal system morphogenesis|
|ossification|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|protein heterodimerization activity|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|circulatory system development|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|apoptotic process|
|animal organ morphogenesis|
|programmed cell death|
|cell death|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.61|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.14|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.12|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.03|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.89|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.85|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2701
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEF2D Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>