======= MEMO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEMO1
  * **<color #00a2e8>Official Name</color>**: mediator of cell motility 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51072|51072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y316|Q9Y316]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEMO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEMO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611786|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Memo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of microtubule-based process|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.46|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.19|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.94|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.87|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.76|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.78|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.81|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.85|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.86|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.86|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.91|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.93|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.94|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.05|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.14|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.19|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.22|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.26|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.31|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.32|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.33|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.53|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.59|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.84|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.84|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.86|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.88|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.9|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.14|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.16|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.21|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.25|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|3.34|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.43|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.45|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.54|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|4.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:ypel5|YPEL5]]|0.587|
|[[:human genes:u:ube2h|UBE2H]]|0.58|
|[[:human genes:w:wdr26|WDR26]]|0.526|
|[[:human genes:a:anp32a|ANP32A]]|0.513|
|[[:human genes:k:kdm6a|KDM6A]]|0.494|
|[[:human genes:c:cdk8|CDK8]]|0.491|
|[[:human genes:f:fam122a|FAM122A]]|0.463|
|[[:human genes:z:znf148|ZNF148]]|0.459|
|[[:human genes:g:gid8|GID8]]|0.435|
|[[:human genes:m:mettl23|METTL23]]|0.426|
|[[:human genes:m:maea|MAEA]]|0.426|
|[[:human genes:s:son|SON]]|0.424|
|[[:human genes:g:gskip|GSKIP]]|0.415|
|[[:human genes:f:fkbp1a|FKBP1A]]|0.414|
|[[:human genes:c:cnot2|CNOT2]]|0.409|
|[[:human genes:a:arid4b|ARID4B]]|0.406|
|[[:human genes:a:ammecr1|AMMECR1]]|0.405|
|[[:human genes:z:zbtb18|ZBTB18]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12735
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEMO1 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>