======= MEN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEN1
  * **<color #00a2e8>Official Name</color>**: menin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4221|4221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00255|O00255]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Menin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Y-form DNA binding|
|negative regulation of telomerase activity|
|regulation of type B pancreatic cell proliferation|
|four-way junction DNA binding|
|osteoblast development|
|histone-lysine N-methyltransferase activity|
|type B pancreatic cell differentiation|
|enteroendocrine cell differentiation|
|R-SMAD binding|
|decidualization|
|regulation of activin receptor signaling pathway|
|beta-catenin-TCF complex assembly|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of cyclin-dependent protein kinase activity|
|maternal placenta development|
|negative regulation of JNK cascade|
|endocrine pancreas development|
|glandular epithelial cell differentiation|
|negative regulation of DNA biosynthetic process|
|histone methyltransferase complex|
|negative regulation of osteoblast differentiation|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|regulation of telomerase activity|
|cleavage furrow|
|response to gamma radiation|
|negative regulation of cell-substrate adhesion|
|maternal process involved in female pregnancy|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|pancreas development|
|histone lysine methylation|
|cellular response to monosaccharide stimulus|
|negative regulation of ossification|
|protein binding, bridging|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|peptidyl-lysine methylation|
|histone methylation|
|positive regulation of protein binding|
|columnar/cuboidal epithelial cell differentiation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|double-stranded DNA binding|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of cell cycle G1/S phase transition|
|protein N-terminus binding|
|nuclear matrix|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|regulation of osteoblast differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|chromatin|
|regulation of cellular response to transforming growth factor beta stimulus|
|endocrine system development|
|negative regulation of DNA metabolic process|
|negative regulation of epithelial cell proliferation|
|osteoblast differentiation|
|negative regulation of protein serine/threonine kinase activity|
|protein alkylation|
|protein methylation|
|response to glucose|
|response to hexose|
|response to UV|
|response to monosaccharide|
|response to ionizing radiation|
|placenta development|
|negative regulation of DNA-binding transcription factor activity|
|response to transforming growth factor beta|
|regulation of cell cycle G1/S phase transition|
|negative regulation of MAPK cascade|
|response to carbohydrate|
|positive regulation of binding|
|female pregnancy|
|glucose homeostasis|
|regulation of JNK cascade|
|carbohydrate homeostasis|
|regulation of ossification|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear chromatin|
|negative regulation of kinase activity|
|macromolecule methylation|
|ossification|
|cellular response to peptide hormone stimulus|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|endoplasmic reticulum lumen|
|response to light stimulus|
|methylation|
|peptidyl-lysine modification|
|negative regulation of cell cycle process|
|cellular response to peptide|
|regulation of epithelial cell proliferation|
|regulation of DNA metabolic process|
|post-translational protein modification|
|histone modification|
|MAPK cascade|
|covalent chromatin modification|
|regulation of binding|
|response to peptide hormone|
|signal transduction by protein phosphorylation|
|chromatin binding|
|negative regulation of protein phosphorylation|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|response to peptide|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|mitotic cell cycle|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|cellular homeostasis|
|response to hormone|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|multi-organism reproductive process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.75|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|7/28|
|bone|1/25|
|breast|2/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|2/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|2/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1226
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEN1 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>