======= MEPCE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEPCE
  * **<color #00a2e8>Official Name</color>**: methylphosphate capping enzyme
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56257|56257]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L2J0|Q7L2J0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEPCE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEPCE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. {ECO:0000269|PubMed:17643375}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 18|
|Bin3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA modification|
|RNA methyltransferase activity|
|snRNA binding|
|O-methyltransferase activity|
|negative regulation of chromatin binding|
|S-adenosylmethionine-dependent methyltransferase activity|
|regulation of chromatin binding|
|positive regulation of G1/S transition of mitotic cell cycle|
|snRNA metabolic process|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of mitotic cell cycle phase transition|
|RNA methylation|
|positive regulation of cell cycle phase transition|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|RNA modification|
|regulation of cell cycle G1/S phase transition|
|negative regulation of binding|
|macromolecule methylation|
|positive regulation of cell cycle process|
|methylation|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|ncRNA metabolic process|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.78|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.453|
|[[:human genes:t:tfip11|TFIP11]]|0.438|
|[[:human genes:h:hexim1|HEXIM1]]|0.437|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.428|
|[[:human genes:p:prpf19|PRPF19]]|0.426|
|[[:human genes:p:psma6|PSMA6]]|0.425|
|[[:human genes:m:madcam1|MADCAM1]]|0.423|
|[[:human genes:a:arhgef15|ARHGEF15]]|0.423|
|[[:human genes:c:cactin|CACTIN]]|0.411|
|[[:human genes:n:nsf|NSF]]|0.411|
|[[:human genes:w:wdr75|WDR75]]|0.41|
|[[:human genes:m:myh7b|MYH7B]]|0.406|
|[[:human genes:e:exosc9|EXOSC9]]|0.406|
|[[:human genes:t:tspy8|TSPY8]]|0.403|
|[[:human genes:c:cgb2|CGB2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 142/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|6/28|
|blood|4/28|
|bone|9/26|
|breast|8/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|4/21|
|liver|3/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|6/26|
|pancreas|0/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|2/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEPCE Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>