======= MET =======
== Gene Information ==
* **Official Symbol**: MET
* **Official Name**: MET proto-oncogene, receptor tyrosine kinase
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4233|4233]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P08581|P08581]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=MET&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MET|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/164860|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016].
* **UniProt Summary**: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.
|PSI|
|Sema|
|Pkinase Tyr|
|TIG|
|Pkinase|
|hepatocyte growth factor-activated receptor activity|
|regulation of thrombin-activated receptor signaling pathway|
|negative regulation of thrombin-activated receptor signaling pathway|
|negative regulation of guanyl-nucleotide exchange factor activity|
|negative regulation of hydrogen peroxide-mediated programmed cell death|
|regulation of guanyl-nucleotide exchange factor activity|
|entry of bacterium into host cell|
|regulation of hydrogen peroxide-mediated programmed cell death|
|regulation of GTP binding|
|semaphorin receptor activity|
|hepatocyte growth factor receptor signaling pathway|
|endothelial cell morphogenesis|
|positive regulation of endothelial cell chemotaxis|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|negative regulation of cellular response to drug|
|regulation of endothelial cell chemotaxis|
|negative regulation of stress fiber assembly|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of Rho protein signal transduction|
|establishment of skin barrier|
|negative regulation of actin filament bundle assembly|
|regulation of water loss via skin|
|negative regulation of response to drug|
|positive regulation of microtubule polymerization|
|epithelial cell morphogenesis|
|positive regulation of microtubule polymerization or depolymerization|
|regulation of response to reactive oxygen species|
|basal plasma membrane|
|regulation of cellular response to drug|
|Wnt-protein binding|
|semaphorin-plexin signaling pathway|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive chemotaxis|
|endothelial cell development|
|regulation of microtubule polymerization|
|negative regulation of Ras protein signal transduction|
|transmembrane receptor protein tyrosine kinase activity|
|negative regulation of small GTPase mediated signal transduction|
|regulation of oxidative stress-induced cell death|
|multicellular organismal water homeostasis|
|pancreas development|
|water homeostasis|
|regulation of cellular response to oxidative stress|
|regulation of stress fiber assembly|
|regulation of microtubule polymerization or depolymerization|
|endothelial cell differentiation|
|negative regulation of autophagy|
|regulation of response to oxidative stress|
|protein phosphatase binding|
|protein tyrosine kinase activity|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|endothelium development|
|regulation of response to drug|
|positive regulation of endothelial cell migration|
|entry into host cell|
|negative regulation of protein binding|
|entry into host|
|liver development|
|positive regulation of protein polymerization|
|hepaticobiliary system development|
|negative regulation of supramolecular fiber organization|
|branching morphogenesis of an epithelial tube|
|positive regulation of chemotaxis|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of Rho protein signal transduction|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|interaction with host|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|positive regulation of protein kinase B signaling|
|morphogenesis of a branching structure|
|negative regulation of binding|
|positive regulation of binding|
|regulation of microtubule cytoskeleton organization|
|epithelial cell development|
|positive regulation of supramolecular fiber organization|
|receptor complex|
|regulation of chemotaxis|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of Ras protein signal transduction|
|positive regulation of protein complex assembly|
|negative regulation of cellular catabolic process|
|regulation of actin filament organization|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|multicellular organismal homeostasis|
|phagocytosis|
|regulation of autophagy|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|MAPK cascade|
|negative regulation of organelle organization|
|regulation of binding|
|skin development|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|gland development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|regulation of body fluid levels|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of organelle organization|
|tube morphogenesis|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|peptidyl-amino acid modification|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of catabolic process|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 14727
* **Expression level (log2 read counts)**: 0.55
{{:chemogenomics:nalm6 dist.png?nolink |}}