======= METAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: METAP1
  * **<color #00a2e8>Official Name</color>**: methionyl aminopeptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23173|23173]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53582|P53582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=METAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20METAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610151|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. {ECO:0000255|HAMAP- Rule:MF_03174, ECO:0000269|PubMed:16274222, ECO:0000269|PubMed:17114291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M24|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein initiator methionine removal|
|metalloexopeptidase activity|
|peptidyl-methionine modification|
|metalloaminopeptidase activity|
|regulation of rhodopsin mediated signaling pathway|
|N-terminal protein amino acid modification|
|aminopeptidase activity|
|platelet aggregation|
|homotypic cell-cell adhesion|
|platelet activation|
|regulation of G protein-coupled receptor signaling pathway|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of translation|
|regulation of cellular amide metabolic process|
|wound healing|
|regulation of body fluid levels|
|cell-cell adhesion|
|posttranscriptional regulation of gene expression|
|response to wounding|
|peptidyl-amino acid modification|
|cell adhesion|
|biological adhesion|
|cell activation|
|regulation of response to external stimulus|
|proteolysis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.36|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.32|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.24|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.82|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.71|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.71|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.78|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.94|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.03|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.33|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.33|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.35|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.83|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:usp32|USP32]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|4/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|6/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='METAP1 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>