======= MGAT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MGAT3
  * **<color #00a2e8>Official Name</color>**: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4248|4248]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q09327|Q09327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MGAT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MGAT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|
|negative regulation of lysosomal protein catabolic process|
|negative regulation of protein catabolic process in the vacuole|
|positive regulation of protein localization to early endosome|
|regulation of protein localization to early endosome|
|regulation of lysosomal protein catabolic process|
|regulation of protein catabolic process in the vacuole|
|positive regulation of protein localization to endosome|
|regulation of protein localization to endosome|
|transferase activity, transferring glycosyl groups|
|N-acetylglucosamine metabolic process|
|amyloid-beta metabolic process|
|glucosamine-containing compound metabolic process|
|amino sugar metabolic process|
|protein N-linked glycosylation|
|negative regulation of cellular protein catabolic process|
|negative regulation of protein catabolic process|
|cellular response to oxidative stress|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|cognition|
|negative regulation of catabolic process|
|glycoprotein biosynthetic process|
|positive regulation of cellular protein localization|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|response to oxidative stress|
|peptide metabolic process|
|regulation of cellular protein localization|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.94|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.76|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3295
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MGAT3 Expression in NALM6 Cells: -0.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>