======= MGST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MGST1
  * **<color #00a2e8>Official Name</color>**: microsomal glutathione S-transferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4257|4257]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10620|P10620]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MGST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MGST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAPEG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to lipid hydroperoxide|
|response to lipid hydroperoxide|
|prostaglandin-E synthase activity|
|cellular response to hydroperoxide|
|Leydig cell differentiation|
|glutathione binding|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|response to hydroperoxide|
|glutathione peroxidase activity|
|glutathione derivative metabolic process|
|glutathione derivative biosynthetic process|
|glutathione transferase activity|
|protein homotrimerization|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|protein trimerization|
|glutathione metabolic process|
|peroxisomal membrane|
|azurophil granule membrane|
|apical part of cell|
|cellular oxidant detoxification|
|fatty acid derivative biosynthetic process|
|cellular detoxification|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|fatty acid biosynthetic process|
|detoxification|
|xenobiotic metabolic process|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|mitochondrial outer membrane|
|fatty acid derivative metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular modified amino acid metabolic process|
|gonad development|
|cellular response to toxic substance|
|development of primary sexual characteristics|
|cellular response to oxidative stress|
|sex differentiation|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to lipopolysaccharide|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|protein homooligomerization|
|sulfur compound metabolic process|
|response to oxidative stress|
|reproductive structure development|
|reproductive system development|
|cofactor metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|response to bacterium|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|response to lipid|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|response to drug|
|organic acid metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|lipid metabolic process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular response to stress|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.24|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.72|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.82|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.85|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.86|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.92|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.93|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.94|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.12|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.26|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MGST1 Expression in NALM6 Cells: 2.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>