======= MID2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MID2
  * **<color #00a2e8>Official Name</color>**: midline 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11043|11043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJV3|Q9UJV3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MID2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MID2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in microtubule stabilization. {ECO:0000303|PubMed:24115387}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
|fn3|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to microtubule|
|negative regulation of viral release from host cell|
|negative regulation of viral entry into host cell|
|negative regulation of viral transcription|
|regulation of viral entry into host cell|
|regulation of viral release from host cell|
|protein localization to microtubule cytoskeleton|
|phosphoprotein binding|
|protein localization to cytoskeleton|
|transferase activity|
|regulation of viral transcription|
|negative regulation of viral life cycle|
|negative regulation of viral process|
|positive regulation of autophagy|
|regulation of viral life cycle|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|microtubule binding|
|positive regulation of DNA-binding transcription factor activity|
|microtubule|
|negative regulation of locomotion|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|protein heterodimerization activity|
|protein ubiquitination|
|protein localization to organelle|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|zinc ion binding|
|protein homodimerization activity|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MID2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>