======= MIER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIER1
  * **<color #00a2e8>Official Name</color>**: MIER1 transcriptional regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57708|57708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N108|Q8N108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chromatin silencing|
|histone deacetylase activity|
|RNA polymerase II repressing transcription factor binding|
|regulation of chromatin silencing|
|histone deacetylation|
|protein deacetylation|
|transcriptional repressor complex|
|protein deacylation|
|macromolecule deacylation|
|positive regulation of chromatin organization|
|histone deacetylase binding|
|regulation of gene silencing|
|positive regulation of chromosome organization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of chromatin organization|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|transcription corepressor activity|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|protein-containing complex|
|positive regulation of organelle organization|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of intracellular signal transduction|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.51|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.9|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.05|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIER1 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>