======= MIOS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIOS
  * **<color #00a2e8>Official Name</color>**: meiosis regulator for oocyte development
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54468|54468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXC5|Q9NXC5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIOS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIOS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GATOR2 complex|
|cellular protein-containing complex localization|
|positive regulation of TOR signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|regulation of TOR signaling|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|protein-containing complex localization|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|cellular response to external stimulus|
|response to nutrient levels|
|response to extracellular stimulus|
|cell junction|
|positive regulation of intracellular signal transduction|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.11|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.76|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.73|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.72|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.8|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.89|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.89|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.92|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.95|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.98|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.02|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.06|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.08|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.18|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.18|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.27|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.28|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.28|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.34|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.39|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.52|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.85|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.12|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.28|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr24|WDR24]]|0.693|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.607|
|[[:human genes:r:rptor|RPTOR]]|0.599|
|[[:human genes:w:wdr59|WDR59]]|0.591|
|[[:human genes:f:fnip1|FNIP1]]|0.564|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.553|
|[[:human genes:m:mtor|MTOR]]|0.533|
|[[:human genes:m:meaf6|MEAF6]]|0.518|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.495|
|[[:human genes:f:flcn|FLCN]]|0.483|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.479|
|[[:human genes:t:tbp|TBP]]|0.475|
|[[:human genes:h:hars|HARS]]|0.469|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.466|
|[[:human genes:r:rraga|RRAGA]]|0.463|
|[[:human genes:e:eif4e|EIF4E]]|0.455|
|[[:human genes:d:dohh|DOHH]]|0.447|
|[[:human genes:m:mlst8|MLST8]]|0.446|
|[[:human genes:f:fbxo11|FBXO11]]|0.437|
|[[:human genes:t:thoc6|THOC6]]|0.429|
|[[:human genes:v:vps41|VPS41]]|0.425|
|[[:human genes:z:znf592|ZNF592]]|0.423|
|[[:human genes:v:vdac2|VDAC2]]|0.422|
|[[:human genes:s:slc7a5|SLC7A5]]|0.419|
|[[:human genes:s:serf2|SERF2]]|0.416|
|[[:human genes:b:bak1|BAK1]]|0.415|
|[[:human genes:e:eif4g1|EIF4G1]]|0.413|
|[[:human genes:i:id3|ID3]]|0.411|
|[[:human genes:e:eny2|ENY2]]|0.409|
|[[:human genes:c:cycs|CYCS]]|0.409|
|[[:human genes:m:mllt1|MLLT1]]|0.408|
|[[:human genes:m:march5|MARCH5]]|0.406|
|[[:human genes:d:diablo|DIABLO]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 64/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|7/28|
|bone|2/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|0/20|
|lung|7/75|
|lymphocyte|4/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIOS Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>