======= MLST8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLST8
  * **<color #00a2e8>Official Name</color>**: MTOR associated protein, LST8 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64223|64223]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVC4|Q9BVC4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLST8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLST8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TORC1 complex|
|TORC1 signaling|
|TORC2 complex|
|TOR signaling|
|protein serine/threonine kinase activator activity|
|activation of protein kinase B activity|
|positive regulation of TOR signaling|
|regulation of cellular response to heat|
|regulation of TOR signaling|
|cell cycle arrest|
|regulation of macroautophagy|
|activation of protein kinase activity|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of cellular response to stress|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|1.71|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.71|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.74|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.75|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.78|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.79|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.82|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.85|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.89|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.91|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.92|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.94|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.94|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.01|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.05|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.06|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.08|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.13|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.16|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.16|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.24|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.35|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.37|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.41|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.52|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.56|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.67|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.69|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.7|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.91|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.23|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.28|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.29|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.32|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.34|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.36|
|[[:results:exp224|CB-839 10μM R05 exp224]]|3.37|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|3.5|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.53|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.57|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.62|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.86|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|4.02|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.32|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|4.4|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|4.42|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|4.92|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|5.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapkap1|MAPKAP1]]|0.753|
|[[:human genes:p:pdpk1|PDPK1]]|0.702|
|[[:human genes:c:cd81|CD81]]|0.669|
|[[:human genes:r:rictor|RICTOR]]|0.661|
|[[:human genes:a:akt2|AKT2]]|0.645|
|[[:human genes:d:dohh|DOHH]]|0.622|
|[[:human genes:m:mtor|MTOR]]|0.601|
|[[:human genes:r:rptor|RPTOR]]|0.583|
|[[:human genes:n:nsd1|NSD1]]|0.573|
|[[:human genes:w:wdr24|WDR24]]|0.564|
|[[:human genes:b:bak1|BAK1]]|0.563|
|[[:human genes:p:pik3cd|PIK3CD]]|0.539|
|[[:human genes:v:vdac2|VDAC2]]|0.535|
|[[:human genes:t:trim28|TRIM28]]|0.534|
|[[:human genes:w:wdr59|WDR59]]|0.524|
|[[:human genes:i:id3|ID3]]|0.521|
|[[:human genes:s:serf2|SERF2]]|0.521|
|[[:human genes:s:syk|SYK]]|0.517|
|[[:human genes:r:romo1|ROMO1]]|0.503|
|[[:human genes:z:zzz3|ZZZ3]]|0.502|
|[[:human genes:f:fbxo11|FBXO11]]|0.496|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.496|
|[[:human genes:b:bap1|BAP1]]|0.493|
|[[:human genes:r:rhoh|RHOH]]|0.479|
|[[:human genes:c:cd19|CD19]]|0.477|
|[[:human genes:a:apaf1|APAF1]]|0.471|
|[[:human genes:m:march5|MARCH5]]|0.465|
|[[:human genes:c:casp9|CASP9]]|0.463|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.461|
|[[:human genes:t:thg1l|THG1L]]|0.455|
|[[:human genes:b:bptf|BPTF]]|0.452|
|[[:human genes:t:trim33|TRIM33]]|0.45|
|[[:human genes:m:mios|MIOS]]|0.446|
|[[:human genes:c:cbfb|CBFB]]|0.444|
|[[:human genes:k:kdsr|KDSR]]|0.442|
|[[:human genes:s:ssbp2|SSBP2]]|0.442|
|[[:human genes:f:faf2|FAF2]]|0.441|
|[[:human genes:r:runx1|RUNX1]]|0.439|
|[[:human genes:k:klf13|KLF13]]|0.439|
|[[:human genes:p:plaa|PLAA]]|0.437|
|[[:human genes:a:asxl2|ASXL2]]|0.433|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.429|
|[[:human genes:n:n6amt1|N6AMT1]]|0.428|
|[[:human genes:v:vhl|VHL]]|0.426|
|[[:human genes:s:stau1|STAU1]]|0.425|
|[[:human genes:u:ubqln1|UBQLN1]]|0.424|
|[[:human genes:t:trnt1|TRNT1]]|0.42|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.419|
|[[:human genes:i:ints10|INTS10]]|0.419|
|[[:human genes:m:mocs3|MOCS3]]|0.419|
|[[:human genes:t:trmt10a|TRMT10A]]|0.417|
|[[:human genes:h:hccs|HCCS]]|0.414|
|[[:human genes:p:pmm2|PMM2]]|0.412|
|[[:human genes:z:znf592|ZNF592]]|0.409|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.406|
|[[:human genes:s:sec62|SEC62]]|0.403|
|[[:human genes:a:asun|ASUN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 162/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|6/28|
|bone|8/26|
|breast|9/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|10/21|
|liver|7/20|
|lung|13/75|
|lymphocyte|6/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLST8 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>