======= MLX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLX
  * **<color #00a2e8>Official Name</color>**: MAX dimerization protein MLX
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6945|6945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UH92|Q9UH92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602976|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear membrane|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|transcription factor binding|
|protein heterodimerization activity|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.78|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.74|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.7|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.83|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.93|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.05|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.11|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.82|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.27|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.49|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.65|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|8.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:txnip|TXNIP]]|0.736|
|[[:human genes:m:mlxip|MLXIP]]|0.664|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6958
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLX Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>