======= MLXIPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLXIPL
  * **<color #00a2e8>Official Name</color>**: MLX interacting protein like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51085|51085]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP71|Q9NP71]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLXIPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLXIPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carbohydrate response element binding|
|hexose mediated signaling|
|glucose mediated signaling pathway|
|sugar mediated signaling pathway|
|carbohydrate mediated signaling|
|negative regulation of oxidative phosphorylation|
|fatty acid homeostasis|
|positive regulation of fatty acid biosynthetic process|
|positive regulation of glycolytic process|
|negative regulation of cell cycle arrest|
|negative regulation of ATP metabolic process|
|negative regulation of peptidyl-serine phosphorylation|
|regulation of oxidative phosphorylation|
|energy homeostasis|
|positive regulation of fatty acid metabolic process|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|regulation of fatty acid biosynthetic process|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|anion homeostasis|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|positive regulation of lipid biosynthetic process|
|cellular response to carbohydrate stimulus|
|regulation of fatty acid metabolic process|
|cellular glucose homeostasis|
|regulation of carbohydrate catabolic process|
|regulation of cell cycle arrest|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|lipid homeostasis|
|regulation of peptidyl-serine phosphorylation|
|response to glucose|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|response to hexose|
|response to monosaccharide|
|regulation of generation of precursor metabolites and energy|
|regulation of cellular ketone metabolic process|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|regulation of carbohydrate metabolic process|
|transcription factor complex|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|multicellular organismal homeostasis|
|negative regulation of cell cycle process|
|transcription factor binding|
|positive regulation of cellular catabolic process|
|positive regulation of cell cycle|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|protein heterodimerization activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|DNA-binding transcription factor activity|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|ion homeostasis|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.92|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.98|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5146
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLXIPL Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>