======= MLYCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLYCD
  * **<color #00a2e8>Official Name</color>**: malonyl-CoA decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23417|23417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95822|O95822]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLYCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLYCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606761|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MCD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|malonyl-CoA catabolic process|
|malonyl-CoA decarboxylase activity|
|malonyl-CoA metabolic process|
|ribonucleoside bisphosphate catabolic process|
|purine nucleoside bisphosphate catabolic process|
|nucleoside bisphosphate catabolic process|
|acetyl-CoA biosynthetic process|
|positive regulation of fatty acid oxidation|
|regulation of fatty acid beta-oxidation|
|regulation of fatty acid oxidation|
|acetyl-CoA metabolic process|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|positive regulation of fatty acid metabolic process|
|purine nucleotide catabolic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|response to ischemia|
|peroxisomal matrix|
|purine-containing compound catabolic process|
|regulation of lipid catabolic process|
|sulfur compound catabolic process|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|nucleotide catabolic process|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|nucleoside phosphate catabolic process|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|regulation of fatty acid metabolic process|
|thioester metabolic process|
|acyl-CoA metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|peroxisome|
|regulation of glucose metabolic process|
|fatty acid biosynthetic process|
|organophosphate catabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of lipid metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|regulation of cellular ketone metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate derivative catabolic process|
|lipid modification|
|regulation of carbohydrate metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein targeting|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|protein localization to organelle|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.97|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.85|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.72|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLYCD Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>