======= MME =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MME
  * **<color #00a2e8>Official Name</color>**: membrane metalloendopeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4311|4311]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08473|P08473]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MME&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MME|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:2972276}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M13|
|Peptidase M13 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|creatinine metabolic process|
|neuropeptide processing|
|cellular lactam metabolic process|
|cellular response to UV-A|
|oligopeptidase activity|
|exopeptidase activity|
|response to UV-A|
|amyloid-beta clearance by cellular catabolic process|
|cellular response to UV-B|
|cardiolipin binding|
|replicative senescence|
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|response to UV-B|
|amyloid-beta metabolic process|
|neuron projection terminus|
|positive regulation of long-term synaptic potentiation|
|amyloid-beta clearance|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|regulation of long-term synaptic potentiation|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|peptide binding|
|brush border|
|phosphatidylserine binding|
|cell aging|
|metallopeptidase activity|
|sensory perception of pain|
|endopeptidase activity|
|cellular response to UV|
|regulation of systemic arterial blood pressure|
|presynapse|
|secretory granule membrane|
|metalloendopeptidase activity|
|cellular response to light stimulus|
|synaptic vesicle|
|response to UV|
|positive regulation of synaptic transmission|
|placenta development|
|protein processing|
|lung development|
|trans-Golgi network|
|respiratory tube development|
|cellular response to radiation|
|regulation of blood pressure|
|regulation of synaptic plasticity|
|respiratory system development|
|hormone metabolic process|
|protein maturation|
|membrane raft|
|cytoplasmic vesicle|
|early endosome|
|learning or memory|
|kidney development|
|synapse|
|aging|
|renal system development|
|axon|
|cognition|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|urogenital system development|
|neuronal cell body|
|blood circulation|
|circulatory system process|
|focal adhesion|
|dendrite|
|reproductive structure development|
|reproductive system development|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|exocytosis|
|regulation of neurogenesis|
|zinc ion binding|
|tube development|
|protein homodimerization activity|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|positive regulation of cell differentiation|
|sensory perception|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cell activation|
|immune effector process|
|response to cytokine|
|secretion|
|response to abiotic stimulus|
|proteolysis|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.83|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.08|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.03|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.87|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.75|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.73|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.71|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.74|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18849
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MME Expression in NALM6 Cells: 10.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>