======= MMP15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP15
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4324|4324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51511|P51511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|Hemopexin|
|PG binding 1|
|DUF3377|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metalloaminopeptidase activity|
|endodermal cell differentiation|
|collagen catabolic process|
|enzyme activator activity|
|endoderm formation|
|collagen metabolic process|
|extracellular matrix disassembly|
|endoderm development|
|metalloendopeptidase activity|
|formation of primary germ layer|
|response to estradiol|
|gastrulation|
|extracellular matrix|
|extracellular matrix organization|
|extracellular structure organization|
|cellular component disassembly|
|embryonic morphogenesis|
|zinc ion binding|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|embryo development|
|proteolysis|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|tissue development|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.77|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.78|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP15 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>