======= MMP19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP19
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4327|4327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99542|Q99542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601807|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. {ECO:0000269|PubMed:10809722, ECO:0000269|PubMed:10922468}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|PG binding 1|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|luteolysis|
|ovulation from ovarian follicle|
|ovulation|
|collagen catabolic process|
|ovulation cycle process|
|ovarian follicle development|
|extracellular matrix disassembly|
|collagen metabolic process|
|ovulation cycle|
|female gonad development|
|development of primary female sexual characteristics|
|response to cAMP|
|metalloendopeptidase activity|
|female sex differentiation|
|female gamete generation|
|response to organophosphorus|
|response to purine-containing compound|
|gonad development|
|development of primary sexual characteristics|
|extracellular matrix|
|sex differentiation|
|rhythmic process|
|angiogenesis|
|extracellular matrix organization|
|extracellular structure organization|
|cellular component disassembly|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to nitrogen compound|
|proteolysis|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.05|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.88|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP19 Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>