======= MMP20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP20
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9313|9313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60882|O60882]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604629|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. {ECO:0000269|PubMed:10922468, ECO:0000269|PubMed:9398237}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|PG binding 1|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of enamel mineralization|
|regulation of tooth mineralization|
|regulation of odontogenesis of dentin-containing tooth|
|amelogenesis|
|regulation of odontogenesis|
|collagen catabolic process|
|collagen metabolic process|
|extracellular matrix disassembly|
|odontogenesis of dentin-containing tooth|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|metalloendopeptidase activity|
|odontogenesis|
|extracellular matrix|
|regulation of animal organ morphogenesis|
|extracellular matrix organization|
|extracellular structure organization|
|cellular component disassembly|
|protein catabolic process|
|zinc ion binding|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|proteolysis|
|extracellular space|
|organic substance catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.77|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP20 Expression in NALM6 Cells: -2.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>