======= MNAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MNAT1
  * **<color #00a2e8>Official Name</color>**: MNAT1 component of CDK activating kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4331|4331]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51948|P51948]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MNAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MNAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602659|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAT1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of DNA helicase activity|
|negative regulation of DNA duplex unwinding|
|cyclin-dependent protein kinase activating kinase holoenzyme complex|
|regulation of DNA helicase activity|
|negative regulation of helicase activity|
|regulation of DNA duplex unwinding|
|cyclin-dependent protein serine/threonine kinase activator activity|
|regulation of helicase activity|
|transcription factor TFIIH holo complex|
|adult heart development|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|negative regulation of ATPase activity|
|ventricular system development|
|transcription elongation from RNA polymerase I promoter|
|nucleotide-excision repair, preincision complex assembly|
|termination of RNA polymerase I transcription|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|7-methylguanosine mRNA capping|
|RNA capping|
|positive regulation of cyclin-dependent protein kinase activity|
|7-methylguanosine RNA capping|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|DNA-dependent ATPase activity|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|regulation of ATPase activity|
|positive regulation of smooth muscle cell proliferation|
|DNA-templated transcription, elongation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|protein N-terminus binding|
|nucleotide-excision repair|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of smooth muscle cell proliferation|
|negative regulation of chromosome organization|
|response to calcium ion|
|transcription initiation from RNA polymerase II promoter|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of protein serine/threonine kinase activity|
|regulation of chromosome organization|
|response to metal ion|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|negative regulation of hydrolase activity|
|mRNA processing|
|transcription by RNA polymerase II|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|heart development|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|brain development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|zinc ion binding|
|cellular protein-containing complex assembly|
|circulatory system development|
|regulation of kinase activity|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.88|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.73|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.71|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf4|TAF4]]|0.405|
|[[:human genes:e:ercc2|ERCC2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 513/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|23/28|
|bone|19/25|
|breast|17/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|17/21|
|liver|13/20|
|lung|52/75|
|lymphocyte|12/14|
|ovary|22/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|2/7|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|19/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 641
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MNAT1 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>