======= MPP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPP5
  * **<color #00a2e8>Official Name</color>**: membrane palmitoylated protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64398|64398]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3R9|Q8N3R9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|L27 N|
|Guanylate kin|
|PDZ|
|SH3 2|
|SH3 1|
|L27|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to myelin sheath abaxonal region|
|lateral loop|
|myelin sheath adaxonal region|
|peripheral nervous system myelin maintenance|
|Schmidt-Lanterman incisure|
|myelin maintenance|
|myelin assembly|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|Schwann cell development|
|establishment of epithelial cell polarity|
|Schwann cell differentiation|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|apical junction assembly|
|morphogenesis of an epithelial sheet|
|peripheral nervous system development|
|endomembrane system|
|plasma membrane organization|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|cell-cell adherens junction|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|establishment of cell polarity|
|bicellular tight junction|
|cell-cell junction organization|
|cell junction assembly|
|glial cell differentiation|
|protein localization to plasma membrane|
|establishment or maintenance of cell polarity|
|cell junction organization|
|gliogenesis|
|protein localization to cell periphery|
|protein domain specific binding|
|endomembrane system organization|
|morphogenesis of an epithelium|
|protein localization to membrane|
|tissue morphogenesis|
|protein-containing complex|
|cellular component morphogenesis|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|epithelium development|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.24|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPP5 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>