======= MRPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL1
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65008|65008]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYD6|Q9BYD6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611821|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L1|
|MRL1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of LSU-rRNA|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|rRNA processing|
|rRNA metabolic process|
|protein-containing complex disassembly|
|ribosome biogenesis|
|translation|
|ncRNA processing|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.8|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.81|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.82|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.89|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.06|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.35|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.48|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fastkd2|FASTKD2]]|0.518|
|[[:human genes:p:pet112|PET112]]|0.493|
|[[:human genes:m:mrps21|MRPS21]]|0.488|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.479|
|[[:human genes:p:pet117|PET117]]|0.477|
|[[:human genes:m:mto1|MTO1]]|0.474|
|[[:human genes:t:timm17a|TIMM17A]]|0.474|
|[[:human genes:m:malsu1|MALSU1]]|0.474|
|[[:human genes:c:coq2|COQ2]]|0.471|
|[[:human genes:r:rpusd4|RPUSD4]]|0.471|
|[[:human genes:i:ict1|ICT1]]|0.467|
|[[:human genes:c:coa3|COA3]]|0.465|
|[[:human genes:n:nars2|NARS2]]|0.465|
|[[:human genes:c:chchd1|CHCHD1]]|0.46|
|[[:human genes:m:mettl17|METTL17]]|0.459|
|[[:human genes:q:qrsl1|QRSL1]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.456|
|[[:human genes:n:ndufb10|NDUFB10]]|0.454|
|[[:human genes:r:rbfa|RBFA]]|0.452|
|[[:human genes:m:mcat|MCAT]]|0.452|
|[[:human genes:m:mrpl21|MRPL21]]|0.451|
|[[:human genes:n:ndufc1|NDUFC1]]|0.448|
|[[:human genes:c:cars2|CARS2]]|0.447|
|[[:human genes:f:fastkd5|FASTKD5]]|0.446|
|[[:human genes:m:mrpl45|MRPL45]]|0.445|
|[[:human genes:m:mrps6|MRPS6]]|0.445|
|[[:human genes:d:dap3|DAP3]]|0.445|
|[[:human genes:g:gfm1|GFM1]]|0.444|
|[[:human genes:m:mrpl47|MRPL47]]|0.443|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.443|
|[[:human genes:e:ears2|EARS2]]|0.441|
|[[:human genes:m:mrps16|MRPS16]]|0.439|
|[[:human genes:s:ssbp1|SSBP1]]|0.439|
|[[:human genes:f:ftsj2|FTSJ2]]|0.439|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.438|
|[[:human genes:n:ndufa11|NDUFA11]]|0.437|
|[[:human genes:d:ddx28|DDX28]]|0.435|
|[[:human genes:m:mtif2|MTIF2]]|0.435|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.435|
|[[:human genes:m:mrpl4|MRPL4]]|0.433|
|[[:human genes:c:c12orf65|C12orf65]]|0.432|
|[[:human genes:r:rmnd1|RMND1]]|0.432|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.431|
|[[:human genes:l:lrpprc|LRPPRC]]|0.429|
|[[:human genes:a:acad9|ACAD9]]|0.428|
|[[:human genes:c:coa6|COA6]]|0.428|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.428|
|[[:human genes:n:ndufb11|NDUFB11]]|0.427|
|[[:human genes:v:vars2|VARS2]]|0.427|
|[[:human genes:m:mrps10|MRPS10]]|0.426|
|[[:human genes:n:ndufa3|NDUFA3]]|0.425|
|[[:human genes:m:mtg2|MTG2]]|0.424|
|[[:human genes:c:clpp|CLPP]]|0.422|
|[[:human genes:l:lars2|LARS2]]|0.422|
|[[:human genes:c:coq4|COQ4]]|0.422|
|[[:human genes:n:ndufc2|NDUFC2]]|0.421|
|[[:human genes:c:cox6a1|COX6A1]]|0.418|
|[[:human genes:s:sco2|SCO2]]|0.415|
|[[:human genes:y:yars2|YARS2]]|0.415|
|[[:human genes:m:mterfd2|MTERFD2]]|0.415|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.413|
|[[:human genes:h:higd2a|HIGD2A]]|0.412|
|[[:human genes:t:tfb1m|TFB1M]]|0.412|
|[[:human genes:n:ndufa1|NDUFA1]]|0.412|
|[[:human genes:m:mrps25|MRPS25]]|0.41|
|[[:human genes:n:ndufb2|NDUFB2]]|0.41|
|[[:human genes:m:mrpl53|MRPL53]]|0.408|
|[[:human genes:e:ecsit|ECSIT]]|0.408|
|[[:human genes:n:ndufb4|NDUFB4]]|0.406|
|[[:human genes:e:eral1|ERAL1]]|0.405|
|[[:human genes:m:mrps27|MRPS27]]|0.402|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.401|
|[[:human genes:m:mrps35|MRPS35]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL1 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>