======= MRPL15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL15
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29088|29088]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P015|Q9P015]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611828|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L18e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular response to cytokine stimulus|
|response to cytokine|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.18|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.08|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.93|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.72|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.76|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.76|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.79|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.93|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.99|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.01|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps14|MRPS14]]|0.644|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.639|
|[[:human genes:d:dap3|DAP3]]|0.622|
|[[:human genes:s:sars2|SARS2]]|0.61|
|[[:human genes:m:mrps5|MRPS5]]|0.606|
|[[:human genes:t:tufm|TUFM]]|0.605|
|[[:human genes:m:mrpl21|MRPL21]]|0.597|
|[[:human genes:n:ndufa3|NDUFA3]]|0.597|
|[[:human genes:y:yars2|YARS2]]|0.596|
|[[:human genes:g:gfm2|GFM2]]|0.591|
|[[:human genes:m:mrpl23|MRPL23]]|0.59|
|[[:human genes:m:mrps34|MRPS34]]|0.588|
|[[:human genes:m:mrp63|MRP63]]|0.587|
|[[:human genes:m:mrpl47|MRPL47]]|0.582|
|[[:human genes:m:mrps6|MRPS6]]|0.58|
|[[:human genes:m:mrps21|MRPS21]]|0.578|
|[[:human genes:t:tars2|TARS2]]|0.568|
|[[:human genes:m:mrps18a|MRPS18A]]|0.568|
|[[:human genes:g:gfm1|GFM1]]|0.567|
|[[:human genes:s:sco2|SCO2]]|0.566|
|[[:human genes:m:mrps16|MRPS16]]|0.561|
|[[:human genes:m:mrpl53|MRPL53]]|0.561|
|[[:human genes:n:ndufb11|NDUFB11]]|0.559|
|[[:human genes:m:mrps33|MRPS33]]|0.559|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.553|
|[[:human genes:t:tefm|TEFM]]|0.552|
|[[:human genes:r:rbfa|RBFA]]|0.551|
|[[:human genes:d:dars2|DARS2]]|0.551|
|[[:human genes:r:rpusd4|RPUSD4]]|0.551|
|[[:human genes:q:qrsl1|QRSL1]]|0.55|
|[[:human genes:m:mrps11|MRPS11]]|0.548|
|[[:human genes:m:mrps26|MRPS26]]|0.547|
|[[:human genes:m:mars2|MARS2]]|0.546|
|[[:human genes:c:cox16|COX16]]|0.543|
|[[:human genes:s:selrc1|SELRC1]]|0.542|
|[[:human genes:p:pars2|PARS2]]|0.542|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.541|
|[[:human genes:m:mrps25|MRPS25]]|0.539|
|[[:human genes:v:vars2|VARS2]]|0.539|
|[[:human genes:n:ndufs7|NDUFS7]]|0.537|
|[[:human genes:m:mrps9|MRPS9]]|0.534|
|[[:human genes:w:wbscr16|WBSCR16]]|0.531|
|[[:human genes:c:chchd4|CHCHD4]]|0.529|
|[[:human genes:n:ndufa2|NDUFA2]]|0.528|
|[[:human genes:c:cox17|COX17]]|0.528|
|[[:human genes:c:c10orf2|C10orf2]]|0.527|
|[[:human genes:r:rpusd3|RPUSD3]]|0.527|
|[[:human genes:b:bcs1l|BCS1L]]|0.526|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.524|
|[[:human genes:h:hars2|HARS2]]|0.523|
|[[:human genes:m:mrpl3|MRPL3]]|0.522|
|[[:human genes:a:atp5sl|ATP5SL]]|0.519|
|[[:human genes:m:mtg2|MTG2]]|0.519|
|[[:human genes:p:pnpt1|PNPT1]]|0.518|
|[[:human genes:f:fars2|FARS2]]|0.518|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.517|
|[[:human genes:c:cox7b|COX7B]]|0.516|
|[[:human genes:n:ndufb3|NDUFB3]]|0.516|
|[[:human genes:f:fastkd5|FASTKD5]]|0.513|
|[[:human genes:c:coa3|COA3]]|0.51|
|[[:human genes:c:cox6c|COX6C]]|0.508|
|[[:human genes:m:mrpl34|MRPL34]]|0.506|
|[[:human genes:p:pdss1|PDSS1]]|0.506|
|[[:human genes:m:mrps24|MRPS24]]|0.505|
|[[:human genes:n:nars2|NARS2]]|0.505|
|[[:human genes:c:c17orf89|C17orf89]]|0.504|
|[[:human genes:c:c12orf65|C12orf65]]|0.504|
|[[:human genes:s:slc25a26|SLC25A26]]|0.502|
|[[:human genes:g:gatc|GATC]]|0.502|
|[[:human genes:m:mrps23|MRPS23]]|0.501|
|[[:human genes:m:mrps12|MRPS12]]|0.501|
|[[:human genes:e:ears2|EARS2]]|0.5|
|[[:human genes:m:mrps2|MRPS2]]|0.498|
|[[:human genes:r:rars2|RARS2]]|0.496|
|[[:human genes:m:mettl17|METTL17]]|0.496|
|[[:human genes:m:mrpl20|MRPL20]]|0.493|
|[[:human genes:n:ndufb5|NDUFB5]]|0.493|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.493|
|[[:human genes:t:triap1|TRIAP1]]|0.493|
|[[:human genes:n:ndufc2|NDUFC2]]|0.493|
|[[:human genes:m:mtpap|MTPAP]]|0.492|
|[[:human genes:p:polg|POLG]]|0.491|
|[[:human genes:n:ndufb9|NDUFB9]]|0.49|
|[[:human genes:c:coq2|COQ2]]|0.489|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.488|
|[[:human genes:e:elac2|ELAC2]]|0.486|
|[[:human genes:n:ndufb6|NDUFB6]]|0.483|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.483|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.48|
|[[:human genes:c:coa6|COA6]]|0.479|
|[[:human genes:n:ndufs2|NDUFS2]]|0.479|
|[[:human genes:t:tomm20|TOMM20]]|0.477|
|[[:human genes:d:dhx30|DHX30]]|0.476|
|[[:human genes:c:chchd1|CHCHD1]]|0.476|
|[[:human genes:n:ndufa11|NDUFA11]]|0.475|
|[[:human genes:m:mrps22|MRPS22]]|0.475|
|[[:human genes:m:mrpl32|MRPL32]]|0.473|
|[[:human genes:m:mrpl55|MRPL55]]|0.472|
|[[:human genes:v:vezt|VEZT]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.469|
|[[:human genes:m:mrpl42|MRPL42]]|0.467|
|[[:human genes:t:tmem126b|TMEM126B]]|0.467|
|[[:human genes:m:mrpl11|MRPL11]]|0.467|
|[[:human genes:m:mrpl12|MRPL12]]|0.466|
|[[:human genes:p:pet112|PET112]]|0.466|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.465|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.463|
|[[:human genes:u:uqcr10|UQCR10]]|0.462|
|[[:human genes:t:timm8b|TIMM8B]]|0.461|
|[[:human genes:i:iba57|IBA57]]|0.46|
|[[:human genes:f:foxred1|FOXRED1]]|0.459|
|[[:human genes:m:mterfd2|MTERFD2]]|0.457|
|[[:human genes:c:coq5|COQ5]]|0.456|
|[[:human genes:c:coq7|COQ7]]|0.454|
|[[:human genes:m:mrpl36|MRPL36]]|0.453|
|[[:human genes:m:mrpl43|MRPL43]]|0.45|
|[[:human genes:m:mrpl27|MRPL27]]|0.45|
|[[:human genes:n:ndufa1|NDUFA1]]|0.45|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.45|
|[[:human genes:p:pgm3|PGM3]]|0.449|
|[[:human genes:p:polrmt|POLRMT]]|0.448|
|[[:human genes:t:tmem261|TMEM261]]|0.446|
|[[:human genes:a:aars2|AARS2]]|0.446|
|[[:human genes:l:lars2|LARS2]]|0.446|
|[[:human genes:m:mrpl44|MRPL44]]|0.446|
|[[:human genes:m:mrpl33|MRPL33]]|0.445|
|[[:human genes:r:rpia|RPIA]]|0.444|
|[[:human genes:p:ptcd3|PTCD3]]|0.443|
|[[:human genes:f:ftsj2|FTSJ2]]|0.443|
|[[:human genes:m:mrpl4|MRPL4]]|0.441|
|[[:human genes:c:cox15|COX15]]|0.44|
|[[:human genes:p:ppa2|PPA2]]|0.439|
|[[:human genes:a:atp5d|ATP5D]]|0.438|
|[[:human genes:p:polg2|POLG2]]|0.436|
|[[:human genes:a:atp5c1|ATP5C1]]|0.435|
|[[:human genes:c:coa5|COA5]]|0.434|
|[[:human genes:t:tfam|TFAM]]|0.434|
|[[:human genes:m:mrpl22|MRPL22]]|0.432|
|[[:human genes:c:cox5a|COX5A]]|0.431|
|[[:human genes:a:atp5a1|ATP5A1]]|0.43|
|[[:human genes:m:mrps7|MRPS7]]|0.43|
|[[:human genes:h:hccs|HCCS]]|0.429|
|[[:human genes:m:mterfd1|MTERFD1]]|0.428|
|[[:human genes:t:tpk1|TPK1]]|0.428|
|[[:human genes:a:alg8|ALG8]]|0.428|
|[[:human genes:a:alg5|ALG5]]|0.427|
|[[:human genes:n:ndufa10|NDUFA10]]|0.426|
|[[:human genes:t:tmem242|TMEM242]]|0.426|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.426|
|[[:human genes:m:mrpl37|MRPL37]]|0.424|
|[[:human genes:t:trmt10c|TRMT10C]]|0.424|
|[[:human genes:e:ecsit|ECSIT]]|0.424|
|[[:human genes:a:angel2|ANGEL2]]|0.423|
|[[:human genes:m:mrpl41|MRPL41]]|0.423|
|[[:human genes:d:dhrsx|DHRSX]]|0.423|
|[[:human genes:a:aifm1|AIFM1]]|0.422|
|[[:human genes:c:cars2|CARS2]]|0.419|
|[[:human genes:g:grsf1|GRSF1]]|0.418|
|[[:human genes:a:atp5j|ATP5J]]|0.417|
|[[:human genes:a:atp5f1|ATP5F1]]|0.417|
|[[:human genes:c:crls1|CRLS1]]|0.417|
|[[:human genes:m:mtif3|MTIF3]]|0.417|
|[[:human genes:a:acad9|ACAD9]]|0.416|
|[[:human genes:t:trub2|TRUB2]]|0.415|
|[[:human genes:f:fastkd1|FASTKD1]]|0.415|
|[[:human genes:a:alg6|ALG6]]|0.415|
|[[:human genes:n:ndufa8|NDUFA8]]|0.414|
|[[:human genes:u:uqcrq|UQCRQ]]|0.414|
|[[:human genes:m:mrpl13|MRPL13]]|0.414|
|[[:human genes:n:ndufb2|NDUFB2]]|0.413|
|[[:human genes:p:ppcs|PPCS]]|0.412|
|[[:human genes:g:gfer|GFER]]|0.412|
|[[:human genes:t:tomm22|TOMM22]]|0.411|
|[[:human genes:n:ndufc1|NDUFC1]]|0.41|
|[[:human genes:p:pitrm1|PITRM1]]|0.409|
|[[:human genes:m:mipep|MIPEP]]|0.408|
|[[:human genes:u:uqcc2|UQCC2]]|0.406|
|[[:human genes:n:ndufv1|NDUFV1]]|0.405|
|[[:human genes:m:mto1|MTO1]]|0.404|
|[[:human genes:a:atxn10|ATXN10]]|0.404|
|[[:human genes:s:srd5a3|SRD5A3]]|0.402|
|[[:human genes:n:nfu1|NFU1]]|0.402|
|[[:human genes:m:mtg1|MTG1]]|0.401|
|[[:human genes:m:mrpl2|MRPL2]]|0.401|
|[[:human genes:f:fastkd2|FASTKD2]]|0.401|
|[[:human genes:i:isca2|ISCA2]]|0.4|
|[[:human genes:m:malsu1|MALSU1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 137/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|4/28|
|blood|6/28|
|bone|2/26|
|breast|7/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|4/21|
|liver|10/20|
|lung|16/75|
|lymphocyte|4/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL15 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>