======= MRPL21 =======
== Gene Information ==
* **Official Symbol**: MRPL21
* **Official Name**: mitochondrial ribosomal protein L21
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=219927|219927]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q7Z2W9|Q7Z2W9]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=MRPL21&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL21|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/611834|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: N/A
|Ribosomal L21p|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.99|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.95|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.8|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.78|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.8|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.8|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.81|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.86|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.94|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.95|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.97|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.05|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.14|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.14|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.16|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.44|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.63|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.9|
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.772|
|[[:human genes:d:dap3|DAP3]]|0.758|
|[[:human genes:r:rpusd4|RPUSD4]]|0.738|
|[[:human genes:m:mrps21|MRPS21]]|0.735|
|[[:human genes:m:mrpl23|MRPL23]]|0.733|
|[[:human genes:y:yars2|YARS2]]|0.731|
|[[:human genes:s:selrc1|SELRC1]]|0.73|
|[[:human genes:m:mrps6|MRPS6]]|0.73|
|[[:human genes:e:ears2|EARS2]]|0.725|
|[[:human genes:n:nars2|NARS2]]|0.725|
|[[:human genes:q:qrsl1|QRSL1]]|0.717|
|[[:human genes:m:mrps34|MRPS34]]|0.717|
|[[:human genes:c:cox16|COX16]]|0.713|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.708|
|[[:human genes:m:mrp63|MRP63]]|0.705|
|[[:human genes:m:mrps5|MRPS5]]|0.699|
|[[:human genes:t:tars2|TARS2]]|0.697|
|[[:human genes:d:dars2|DARS2]]|0.695|
|[[:human genes:m:mrps14|MRPS14]]|0.693|
|[[:human genes:g:gfm1|GFM1]]|0.692|
|[[:human genes:l:lars2|LARS2]]|0.691|
|[[:human genes:t:tufm|TUFM]]|0.69|
|[[:human genes:m:mrps18a|MRPS18A]]|0.686|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.685|
|[[:human genes:s:sco2|SCO2]]|0.685|
|[[:human genes:m:mrpl47|MRPL47]]|0.683|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.676|
|[[:human genes:p:pars2|PARS2]]|0.676|
|[[:human genes:m:mrps16|MRPS16]]|0.676|
|[[:human genes:f:fastkd5|FASTKD5]]|0.674|
|[[:human genes:b:bcs1l|BCS1L]]|0.674|
|[[:human genes:n:ndufa3|NDUFA3]]|0.669|
|[[:human genes:m:mtg2|MTG2]]|0.659|
|[[:human genes:w:wbscr16|WBSCR16]]|0.654|
|[[:human genes:s:slc25a26|SLC25A26]]|0.652|
|[[:human genes:m:mrps26|MRPS26]]|0.651|
|[[:human genes:v:vars2|VARS2]]|0.648|
|[[:human genes:m:mrpl53|MRPL53]]|0.646|
|[[:human genes:r:rars2|RARS2]]|0.646|
|[[:human genes:h:hars2|HARS2]]|0.639|
|[[:human genes:f:ftsj2|FTSJ2]]|0.639|
|[[:human genes:r:rbfa|RBFA]]|0.639|
|[[:human genes:t:trub2|TRUB2]]|0.637|
|[[:human genes:p:pnpt1|PNPT1]]|0.632|
|[[:human genes:s:sars2|SARS2]]|0.629|
|[[:human genes:n:ndufb11|NDUFB11]]|0.625|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.622|
|[[:human genes:g:gfm2|GFM2]]|0.622|
|[[:human genes:m:mrps9|MRPS9]]|0.616|
|[[:human genes:m:mrps25|MRPS25]]|0.615|
|[[:human genes:m:mtpap|MTPAP]]|0.614|
|[[:human genes:g:gatc|GATC]]|0.613|
|[[:human genes:c:c12orf65|C12orf65]]|0.611|
|[[:human genes:m:mrps2|MRPS2]]|0.607|
|[[:human genes:m:mrpl12|MRPL12]]|0.605|
|[[:human genes:t:tefm|TEFM]]|0.605|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.604|
|[[:human genes:p:pet112|PET112]]|0.601|
|[[:human genes:t:tmem242|TMEM242]]|0.601|
|[[:human genes:m:mrps12|MRPS12]]|0.599|
|[[:human genes:m:mrpl15|MRPL15]]|0.597|
|[[:human genes:m:mtg1|MTG1]]|0.596|
|[[:human genes:m:mrpl20|MRPL20]]|0.595|
|[[:human genes:a:atp5c1|ATP5C1]]|0.595|
|[[:human genes:m:mrpl45|MRPL45]]|0.593|
|[[:human genes:m:mrpl44|MRPL44]]|0.592|
|[[:human genes:c:coa3|COA3]]|0.59|
|[[:human genes:m:mrps10|MRPS10]]|0.59|
|[[:human genes:c:c10orf2|C10orf2]]|0.589|
|[[:human genes:m:mars2|MARS2]]|0.588|
|[[:human genes:c:cox7b|COX7B]]|0.587|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.586|
|[[:human genes:m:mrps23|MRPS23]]|0.586|
|[[:human genes:a:atp5d|ATP5D]]|0.585|
|[[:human genes:c:c17orf89|C17orf89]]|0.583|
|[[:human genes:f:fars2|FARS2]]|0.582|
|[[:human genes:t:tomm20|TOMM20]]|0.582|
|[[:human genes:a:aars2|AARS2]]|0.582|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.582|
|[[:human genes:n:ndufc2|NDUFC2]]|0.582|
|[[:human genes:m:mrps11|MRPS11]]|0.582|
|[[:human genes:m:mrpl42|MRPL42]]|0.582|
|[[:human genes:p:pgm3|PGM3]]|0.58|
|[[:human genes:m:mrpl55|MRPL55]]|0.579|
|[[:human genes:a:atp5a1|ATP5A1]]|0.578|
|[[:human genes:r:rpusd3|RPUSD3]]|0.577|
|[[:human genes:m:mrps24|MRPS24]]|0.573|
|[[:human genes:m:mrpl3|MRPL3]]|0.571|
|[[:human genes:c:chchd1|CHCHD1]]|0.569|
|[[:human genes:d:dhrsx|DHRSX]]|0.567|
|[[:human genes:p:pdss1|PDSS1]]|0.566|
|[[:human genes:u:uqcr10|UQCR10]]|0.566|
|[[:human genes:p:pet117|PET117]]|0.565|
|[[:human genes:m:mettl17|METTL17]]|0.565|
|[[:human genes:c:cox11|COX11]]|0.562|
|[[:human genes:n:ndufb5|NDUFB5]]|0.562|
|[[:human genes:m:mrpl33|MRPL33]]|0.561|
|[[:human genes:n:ndufa1|NDUFA1]]|0.56|
|[[:human genes:c:cox15|COX15]]|0.558|
|[[:human genes:e:elac2|ELAC2]]|0.556|
|[[:human genes:c:coq3|COQ3]]|0.553|
|[[:human genes:c:chchd4|CHCHD4]]|0.553|
|[[:human genes:m:mrps35|MRPS35]]|0.553|
|[[:human genes:c:coq2|COQ2]]|0.551|
|[[:human genes:m:mipep|MIPEP]]|0.55|
|[[:human genes:m:mrpl43|MRPL43]]|0.55|
|[[:human genes:m:mrps33|MRPS33]]|0.549|
|[[:human genes:a:atp5b|ATP5B]]|0.549|
|[[:human genes:c:cox17|COX17]]|0.548|
|[[:human genes:n:ndufa2|NDUFA2]]|0.547|
|[[:human genes:n:ndufb6|NDUFB6]]|0.546|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.545|
|[[:human genes:m:mrpl39|MRPL39]]|0.541|
|[[:human genes:p:polg2|POLG2]]|0.54|
|[[:human genes:p:polg|POLG]]|0.54|
|[[:human genes:p:polrmt|POLRMT]]|0.539|
|[[:human genes:t:tfam|TFAM]]|0.536|
|[[:human genes:i:iba57|IBA57]]|0.532|
|[[:human genes:m:mrpl27|MRPL27]]|0.531|
|[[:human genes:f:fh|FH]]|0.531|
|[[:human genes:d:dnlz|DNLZ]]|0.53|
|[[:human genes:a:aifm1|AIFM1]]|0.529|
|[[:human genes:c:coq7|COQ7]]|0.528|
|[[:human genes:m:mrpl18|MRPL18]]|0.528|
|[[:human genes:c:coa6|COA6]]|0.528|
|[[:human genes:m:mrpl4|MRPL4]]|0.527|
|[[:human genes:m:mrps22|MRPS22]]|0.527|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.526|
|[[:human genes:t:triap1|TRIAP1]]|0.523|
|[[:human genes:m:mrps17|MRPS17]]|0.523|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.522|
|[[:human genes:t:tomm22|TOMM22]]|0.522|
|[[:human genes:c:clpp|CLPP]]|0.521|
|[[:human genes:m:mrpl36|MRPL36]]|0.521|
|[[:human genes:n:ndufb9|NDUFB9]]|0.521|
|[[:human genes:n:ndufb3|NDUFB3]]|0.52|
|[[:human genes:c:cars2|CARS2]]|0.519|
|[[:human genes:m:mrpl41|MRPL41]]|0.519|
|[[:human genes:d:dhx30|DHX30]]|0.518|
|[[:human genes:a:atp5sl|ATP5SL]]|0.517|
|[[:human genes:n:ndufs2|NDUFS2]]|0.517|
|[[:human genes:u:uqcc2|UQCC2]]|0.515|
|[[:human genes:r:rpia|RPIA]]|0.513|
|[[:human genes:n:ndufv1|NDUFV1]]|0.513|
|[[:human genes:m:mrpl46|MRPL46]]|0.513|
|[[:human genes:m:mrpl22|MRPL22]]|0.512|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.512|
|[[:human genes:n:ndufa11|NDUFA11]]|0.509|
|[[:human genes:m:mrpl34|MRPL34]]|0.508|
|[[:human genes:c:cox6b1|COX6B1]]|0.507|
|[[:human genes:o:opa1|OPA1]]|0.506|
|[[:human genes:m:mterfd2|MTERFD2]]|0.506|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.506|
|[[:human genes:c:coa5|COA5]]|0.506|
|[[:human genes:a:acad9|ACAD9]]|0.505|
|[[:human genes:m:mterfd1|MTERFD1]]|0.505|
|[[:human genes:c:coq4|COQ4]]|0.502|
|[[:human genes:a:atp5o|ATP5O]]|0.502|
|[[:human genes:h:higd2a|HIGD2A]]|0.502|
|[[:human genes:d:ddx28|DDX28]]|0.501|
|[[:human genes:m:mrps7|MRPS7]]|0.5|
|[[:human genes:m:mrpl13|MRPL13]]|0.499|
|[[:human genes:h:hccs|HCCS]]|0.499|
|[[:human genes:m:mrps28|MRPS28]]|0.499|
|[[:human genes:p:ppa2|PPA2]]|0.497|
|[[:human genes:s:ssbp1|SSBP1]]|0.493|
|[[:human genes:t:tomm6|TOMM6]]|0.492|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.489|
|[[:human genes:m:mrpl11|MRPL11]]|0.487|
|[[:human genes:m:mrpl52|MRPL52]]|0.486|
|[[:human genes:m:mtif3|MTIF3]]|0.485|
|[[:human genes:t:tamm41|TAMM41]]|0.485|
|[[:human genes:t:tfb1m|TFB1M]]|0.483|
|[[:human genes:l:lrpprc|LRPPRC]]|0.482|
|[[:human genes:w:wars2|WARS2]]|0.481|
|[[:human genes:l:lsm10|LSM10]]|0.481|
|[[:human genes:t:timm8b|TIMM8B]]|0.481|
|[[:human genes:n:ndufs7|NDUFS7]]|0.48|
|[[:human genes:c:crls1|CRLS1]]|0.477|
|[[:human genes:p:ppcs|PPCS]]|0.477|
|[[:human genes:m:mrpl49|MRPL49]]|0.474|
|[[:human genes:c:cox5a|COX5A]]|0.473|
|[[:human genes:m:malsu1|MALSU1]]|0.473|
|[[:human genes:c:cox6c|COX6C]]|0.472|
|[[:human genes:m:mtif2|MTIF2]]|0.471|
|[[:human genes:p:pmvk|PMVK]]|0.471|
|[[:human genes:t:tpk1|TPK1]]|0.47|
|[[:human genes:p:pet100|PET100]]|0.469|
|[[:human genes:c:coq6|COQ6]]|0.469|
|[[:human genes:s:slc25a3|SLC25A3]]|0.469|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.467|
|[[:human genes:u:uqcrq|UQCRQ]]|0.467|
|[[:human genes:n:ndufb1|NDUFB1]]|0.467|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.467|
|[[:human genes:n:ndufs1|NDUFS1]]|0.464|
|[[:human genes:t:trmt61a|TRMT61A]]|0.463|
|[[:human genes:g:glrx5|GLRX5]]|0.463|
|[[:human genes:c:cox20|COX20]]|0.462|
|[[:human genes:i:ict1|ICT1]]|0.461|
|[[:human genes:a:atp5j|ATP5J]]|0.459|
|[[:human genes:e:ecsit|ECSIT]]|0.458|
|[[:human genes:a:atp5f1|ATP5F1]]|0.458|
|[[:human genes:t:timm17a|TIMM17A]]|0.458|
|[[:human genes:c:cycs|CYCS]]|0.457|
|[[:human genes:m:mrpl24|MRPL24]]|0.457|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.455|
|[[:human genes:p:ptcd1|PTCD1]]|0.455|
|[[:human genes:t:trmt10c|TRMT10C]]|0.454|
|[[:human genes:p:ppcdc|PPCDC]]|0.453|
|[[:human genes:f:fastkd2|FASTKD2]]|0.452|
|[[:human genes:m:mrpl1|MRPL1]]|0.451|
|[[:human genes:t:tomm40|TOMM40]]|0.45|
|[[:human genes:g:g6pd|G6PD]]|0.449|
|[[:human genes:r:romo1|ROMO1]]|0.447|
|[[:human genes:t:taz|TAZ]]|0.447|
|[[:human genes:a:atp5e|ATP5E]]|0.447|
|[[:human genes:n:nfu1|NFU1]]|0.447|
|[[:human genes:m:mrps27|MRPS27]]|0.446|
|[[:human genes:u:uap1|UAP1]]|0.446|
|[[:human genes:a:alas1|ALAS1]]|0.444|
|[[:human genes:g:grsf1|GRSF1]]|0.443|
|[[:human genes:n:ndufa8|NDUFA8]]|0.443|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.443|
|[[:human genes:p:pmm2|PMM2]]|0.443|
|[[:human genes:t:tmem261|TMEM261]]|0.442|
|[[:human genes:p:pitrm1|PITRM1]]|0.442|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.44|
|[[:human genes:m:mrpl51|MRPL51]]|0.44|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.439|
|[[:human genes:a:atxn10|ATXN10]]|0.439|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.439|
|[[:human genes:a:alg6|ALG6]]|0.439|
|[[:human genes:f:fech|FECH]]|0.438|
|[[:human genes:m:mrpl38|MRPL38]]|0.438|
|[[:human genes:s:slc25a19|SLC25A19]]|0.436|
|[[:human genes:a:atic|ATIC]]|0.436|
|[[:human genes:c:cox19|COX19]]|0.435|
|[[:human genes:m:mrpl35|MRPL35]]|0.435|
|[[:human genes:n:nubpl|NUBPL]]|0.434|
|[[:human genes:n:ndufc1|NDUFC1]]|0.434|
|[[:human genes:m:mrpl2|MRPL2]]|0.433|
|[[:human genes:t:tfb2m|TFB2M]]|0.432|
|[[:human genes:m:minos1|MINOS1]]|0.432|
|[[:human genes:f:fastkd1|FASTKD1]]|0.431|
|[[:human genes:v:vezt|VEZT]]|0.43|
|[[:human genes:a:atp5h|ATP5H]]|0.429|
|[[:human genes:s:srd5a3|SRD5A3]]|0.429|
|[[:human genes:m:mrpl32|MRPL32]]|0.429|
|[[:human genes:d:dohh|DOHH]]|0.428|
|[[:human genes:m:mtrf1|MTRF1]]|0.427|
|[[:human genes:n:ndufa10|NDUFA10]]|0.426|
|[[:human genes:t:thg1l|THG1L]]|0.426|
|[[:human genes:c:coq5|COQ5]]|0.425|
|[[:human genes:m:mto1|MTO1]]|0.424|
|[[:human genes:c:c1qbp|C1QBP]]|0.423|
|[[:human genes:m:mrpl37|MRPL37]]|0.422|
|[[:human genes:n:ndufs5|NDUFS5]]|0.422|
|[[:human genes:t:tomm7|TOMM7]]|0.419|
|[[:human genes:s:slc25a52|SLC25A52]]|0.419|
|[[:human genes:a:alg8|ALG8]]|0.417|
|[[:human genes:t:tmem126b|TMEM126B]]|0.417|
|[[:human genes:m:mrpl17|MRPL17]]|0.416|
|[[:human genes:m:mcat|MCAT]]|0.416|
|[[:human genes:m:mrpl19|MRPL19]]|0.415|
|[[:human genes:m:mrpl28|MRPL28]]|0.415|
|[[:human genes:s:ssb|SSB]]|0.413|
|[[:human genes:r:rpe|RPE]]|0.413|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.412|
|[[:human genes:p:ptdss1|PTDSS1]]|0.411|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.41|
|[[:human genes:k:kdsr|KDSR]]|0.41|
|[[:human genes:p:ptcd3|PTCD3]]|0.409|
|[[:human genes:g:gemin7|GEMIN7]]|0.408|
|[[:human genes:e:eral1|ERAL1]]|0.407|
|[[:human genes:t:tbrg4|TBRG4]]|0.406|
|[[:human genes:t:ttc4|TTC4]]|0.406|
|[[:human genes:a:atp5l|ATP5L]]|0.405|
|[[:human genes:m:mrpl9|MRPL9]]|0.405|
|[[:human genes:z:zrsr2|ZRSR2]]|0.405|
|[[:human genes:n:ndufa6|NDUFA6]]|0.404|
|[[:human genes:c:cox7c|COX7C]]|0.403|
|[[:human genes:n:ndufb7|NDUFB7]]|0.403|
|[[:human genes:n:ndufb2|NDUFB2]]|0.403|
|[[:human genes:n:ndufb4|NDUFB4]]|0.402|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.401|
|[[:human genes:c:cox10|COX10]]|0.401|
Global Fraction of Cell Lines Where Essential: 597/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|24/28|
|bone|18/26|
|breast|27/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|12/21|
|liver|17/20|
|lung|64/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|16/24|
|peripheral nervous system|12/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|4/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 575
* **Expression level (log2 read counts)**: 4.9
{{:chemogenomics:nalm6 dist.png?nolink |}}