======= MRPL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL4
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51073|51073]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYD3|Q9BYD3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611823|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.24|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.77|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.71|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.7|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.8|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.81|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.01|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.589|
|[[:human genes:p:pet112|PET112]]|0.565|
|[[:human genes:n:nars2|NARS2]]|0.562|
|[[:human genes:m:mrps34|MRPS34]]|0.557|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.557|
|[[:human genes:m:mrps14|MRPS14]]|0.543|
|[[:human genes:m:mrpl47|MRPL47]]|0.543|
|[[:human genes:m:mrps6|MRPS6]]|0.542|
|[[:human genes:m:mrpl23|MRPL23]]|0.542|
|[[:human genes:f:ftsj2|FTSJ2]]|0.541|
|[[:human genes:d:dap3|DAP3]]|0.541|
|[[:human genes:p:pars2|PARS2]]|0.539|
|[[:human genes:a:aars2|AARS2]]|0.535|
|[[:human genes:m:mrps21|MRPS21]]|0.535|
|[[:human genes:y:yars2|YARS2]]|0.531|
|[[:human genes:m:mrpl21|MRPL21]]|0.527|
|[[:human genes:r:rpusd4|RPUSD4]]|0.526|
|[[:human genes:m:mrpl53|MRPL53]]|0.523|
|[[:human genes:s:selrc1|SELRC1]]|0.523|
|[[:human genes:m:mrps16|MRPS16]]|0.512|
|[[:human genes:t:tars2|TARS2]]|0.511|
|[[:human genes:l:lars2|LARS2]]|0.507|
|[[:human genes:w:wbscr16|WBSCR16]]|0.506|
|[[:human genes:v:vars2|VARS2]]|0.502|
|[[:human genes:f:fastkd5|FASTKD5]]|0.498|
|[[:human genes:s:sco2|SCO2]]|0.494|
|[[:human genes:f:fars2|FARS2]]|0.494|
|[[:human genes:m:mrps25|MRPS25]]|0.493|
|[[:human genes:p:pet117|PET117]]|0.491|
|[[:human genes:m:malsu1|MALSU1]]|0.49|
|[[:human genes:m:mettl17|METTL17]]|0.488|
|[[:human genes:c:coa3|COA3]]|0.487|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.486|
|[[:human genes:s:sars2|SARS2]]|0.486|
|[[:human genes:g:gfm2|GFM2]]|0.485|
|[[:human genes:r:rars2|RARS2]]|0.484|
|[[:human genes:l:lrpprc|LRPPRC]]|0.483|
|[[:human genes:m:mrps5|MRPS5]]|0.483|
|[[:human genes:m:mrps10|MRPS10]]|0.482|
|[[:human genes:g:gfm1|GFM1]]|0.475|
|[[:human genes:m:mrpl22|MRPL22]]|0.474|
|[[:human genes:m:mtg2|MTG2]]|0.474|
|[[:human genes:p:polrmt|POLRMT]]|0.474|
|[[:human genes:f:fastkd2|FASTKD2]]|0.472|
|[[:human genes:m:mrps35|MRPS35]]|0.472|
|[[:human genes:m:mrpl3|MRPL3]]|0.47|
|[[:human genes:m:mrpl45|MRPL45]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.47|
|[[:human genes:m:mrps26|MRPS26]]|0.469|
|[[:human genes:d:dars2|DARS2]]|0.468|
|[[:human genes:m:mrp63|MRP63]]|0.466|
|[[:human genes:m:mrps12|MRPS12]]|0.464|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.461|
|[[:human genes:e:ears2|EARS2]]|0.461|
|[[:human genes:m:mtg1|MTG1]]|0.46|
|[[:human genes:h:hars2|HARS2]]|0.46|
|[[:human genes:r:rbfa|RBFA]]|0.46|
|[[:human genes:m:mrps18a|MRPS18A]]|0.457|
|[[:human genes:c:coa6|COA6]]|0.456|
|[[:human genes:c:cox17|COX17]]|0.455|
|[[:human genes:m:mrpl39|MRPL39]]|0.454|
|[[:human genes:m:mrps23|MRPS23]]|0.454|
|[[:human genes:s:ssbp1|SSBP1]]|0.454|
|[[:human genes:c:coq2|COQ2]]|0.453|
|[[:human genes:n:ndufb11|NDUFB11]]|0.452|
|[[:human genes:m:mrps24|MRPS24]]|0.452|
|[[:human genes:r:rpusd3|RPUSD3]]|0.452|
|[[:human genes:m:mars2|MARS2]]|0.451|
|[[:human genes:t:trub2|TRUB2]]|0.449|
|[[:human genes:m:mterfd2|MTERFD2]]|0.446|
|[[:human genes:p:polg2|POLG2]]|0.445|
|[[:human genes:m:mrps27|MRPS27]]|0.444|
|[[:human genes:c:cox16|COX16]]|0.442|
|[[:human genes:m:mrpl15|MRPL15]]|0.441|
|[[:human genes:m:mterfd1|MTERFD1]]|0.44|
|[[:human genes:n:ndufb6|NDUFB6]]|0.439|
|[[:human genes:m:mrps22|MRPS22]]|0.434|
|[[:human genes:m:mrpl1|MRPL1]]|0.433|
|[[:human genes:m:mrpl55|MRPL55]]|0.432|
|[[:human genes:m:mrpl12|MRPL12]]|0.432|
|[[:human genes:m:mrpl18|MRPL18]]|0.431|
|[[:human genes:c:c10orf2|C10orf2]]|0.43|
|[[:human genes:p:pnpt1|PNPT1]]|0.429|
|[[:human genes:c:c12orf65|C12orf65]]|0.428|
|[[:human genes:g:grsf1|GRSF1]]|0.428|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.426|
|[[:human genes:t:tufm|TUFM]]|0.425|
|[[:human genes:c:coa5|COA5]]|0.425|
|[[:human genes:m:mrpl33|MRPL33]]|0.423|
|[[:human genes:m:mrpl42|MRPL42]]|0.422|
|[[:human genes:g:gatc|GATC]]|0.421|
|[[:human genes:p:pitrm1|PITRM1]]|0.42|
|[[:human genes:m:mrpl41|MRPL41]]|0.417|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.416|
|[[:human genes:t:tomm20|TOMM20]]|0.415|
|[[:human genes:n:ndufs5|NDUFS5]]|0.414|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.413|
|[[:human genes:m:mrps9|MRPS9]]|0.412|
|[[:human genes:n:ndufa3|NDUFA3]]|0.411|
|[[:human genes:n:ndufa2|NDUFA2]]|0.411|
|[[:human genes:b:bcs1l|BCS1L]]|0.409|
|[[:human genes:c:cox11|COX11]]|0.409|
|[[:human genes:n:ndufa11|NDUFA11]]|0.409|
|[[:human genes:m:mrpl2|MRPL2]]|0.409|
|[[:human genes:m:mrpl52|MRPL52]]|0.408|
|[[:human genes:c:cars2|CARS2]]|0.408|
|[[:human genes:a:aifm1|AIFM1]]|0.408|
|[[:human genes:m:mrpl49|MRPL49]]|0.408|
|[[:human genes:t:tomm22|TOMM22]]|0.407|
|[[:human genes:m:mto1|MTO1]]|0.407|
|[[:human genes:d:dhx30|DHX30]]|0.406|
|[[:human genes:m:mtif3|MTIF3]]|0.405|
|[[:human genes:m:mrpl43|MRPL43]]|0.404|
|[[:human genes:a:atp5sl|ATP5SL]]|0.404|
|[[:human genes:m:mrpl44|MRPL44]]|0.403|
|[[:human genes:m:mcat|MCAT]]|0.403|
|[[:human genes:m:mrpl28|MRPL28]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 294/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|6/28|
|bone|9/26|
|breast|13/33|
|central nervous system|24/56|
|cervix|4/4|
|colorectal|8/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|6/21|
|liver|11/20|
|lung|34/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|3/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 483
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL4 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>